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Novel method for extraction of tyrosine from hairs through one-step refining process

A refining method and tyrosine technology, applied in the field of tyrosine extraction, can solve the problems of polluting the environment, decreasing the yield of cystine, and affecting the production environment of the workshop, so as to reduce environmental pollution, shorten the production cycle, and increase the yield Effect

Inactive Publication Date: 2015-04-01
重庆工贸职业技术学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the second step of alkaline dissolution process, due to strong alkalinity and high temperature, the cystine coexisting in the crude tyrosine I is partially decomposed, resulting in a decrease in the yield of cystine
At the same time, the decomposition products have the stench of rotten eggs, which seriously affects the production environment of the workshop
In this step, the waste liquid after recycling cystine is almost completely useless, and it is discharged as waste liquid and seriously pollutes the environment because ammonia nitrogen exceeds the standard.

Method used

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  • Novel method for extraction of tyrosine from hairs through one-step refining process
  • Novel method for extraction of tyrosine from hairs through one-step refining process

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Take 2.5L of the refined mother liquor for extracting cystine from pig hair (equivalent to 1000g pig hair), heat it up to 60°C, quickly neutralize it with concentrated ammonia water to pH8.5 under stirring, and filter while it is hot. Precipitated as crude tyrosine. The filtrate is the primary mother liquor, which can be counter-neutralized to about pH 5 with hydrochloric acid, cooled and settled for one day, and filtered to recover cystine. Transfer the crude tyrosine into a beaker, add dilute hydrochloric acid until the crude product is completely dissolved, control the volume at 400mL, heat to 70-80°C, add 10g of activated carbon, stir for 0.5-2h to decolorize, filter and wash to obtain a decolorized solution. The volume is controlled at 500mL. Put the decolorizing solution in a beaker, slowly neutralize it with dilute ammonia water to pH 1.8 at 50-80°C, cool to 40°C, filter and wash to obtain 16.8g of tyrosine product. The light transmittance of the product is 95....

Embodiment 2

[0025] Take 2L of refined mother liquor (equivalent to 1000g chicken feathers) for extracting cystine from chicken feathers, heat up to 60°C, quickly neutralize to pH9.0 with concentrated ammonia water under stirring, and filter while hot. Precipitated as crude tyrosine. The filtrate is the primary mother liquor, which can be counter-neutralized to about pH 5 with hydrochloric acid, cooled and settled for one day, and filtered to recover cystine. Transfer the crude tyrosine into a beaker, add dilute hydrochloric acid until the crude product is completely dissolved, control the volume at 800mL, heat to 70-80°C, add 10g of activated carbon, stir for 0.5-2 hours to decolorize, filter, and wash to obtain a decolorized solution. The volume is controlled at 1000mL. Put the decolorizing solution in a beaker, slowly neutralize it with dilute ammonia water to pH 2.0 at 50-80°C, cool to 40°C, filter and wash to obtain 24.3g of finished tyrosine. The light transmittance of the product ...

Embodiment 3

[0026] Embodiment 3 (comparative example)

[0027] Take 2.5 L of refined mother liquor (equivalent to 1000 g of pig hair) for extracting cystine from pig hair, neutralize it with concentrated ammonia water to pH 4.8, let it settle for two days, and filter. The filtrate is the primary mother liquor, and the precipitate is the crude tyrosine I. Transfer the crude tyrosine I into a beaker, add 200mL of water, raise the temperature to 60°C, add 30% NaOH solution at the same time until the crude product dissolves, control the volume at 300mL, add 5g of activated carbon, and stir at 50-60°C for 0.5 ~2h, filter and wash. Put the decolorized solution in a beaker, slowly neutralize it to pH9.0 with 6mol / L hydrochloric acid at 50-60°C, and filter. The precipitate is the crude tyrosine II, and the filtrate is the secondary mother liquor, which can be further neutralized with hydrochloric acid to about pH5, cooled and settled for one day, and filtered to obtain cystine. Transfer the cr...

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Abstract

The invention provides a novel method for extraction of tyrosine from hairs through a one-step refining process, which relates to an extraction method for tyrosine. According to the invention, refined cystine mother liquor is rapidly neutralized to a high pH value and separated while the mother liquor is hot, so a crude product of tyrosine with low content of cystine can be prepared, which facilitates preparation of a finished product of tyrosine through the one-step refining process. With the method provided by the invention, the steps of alkali dissolution, decolouring and neutralization are omitted, so a production period is shortened, environmental pollution is reduced, and yield of tyrosine products is respectively improved by more than 0.4%.

Description

Technical field: [0001] The invention relates to a method for extracting tyrosine, in particular to a novel method for extracting tyrosine from hair by one-step refining. Background technique: [0002] Tyrosine is an important pharmaceutical raw material. Extracting from hair is an important way to produce tyrosine. The usual method is to hydrolyze hair acid, then neutralize and extract cystine, and then extract tyrosine from the mother liquor after refining cystine. [0003] Publication No. CN1231284A titled "New Method for Separation and Extraction of L-Tyrosine and L-Cystine Simultaneously" proposes to neutralize the effluent from the production of L-cystine to obtain L-tyrosine and L-cystine The mixed crude product of L-cystine is separated by a two-step refining method according to the difference in solubility of the two to obtain L-tyrosine. For the process flow of this method, see figure 1 . [0004] As shown in the figure: the main points of this method are: the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/36C07C227/40C07C323/58C07C319/28
Inventor 刘勋
Owner 重庆工贸职业技术学院
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