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Novel piracetam drug co-crystal and preparation method thereof

A piracetam and drug technology, applied in the field of novel piracetam co-crystal and its preparation, to achieve the effect of improving stability and bioavailability

Inactive Publication Date: 2013-04-17
JILIN INST OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drug crystal form research and solid-state characterization of drugs are relatively mature and highly valued fields in the European and American pharmaceutical industry, but they are still in their infancy in the domestic pharmaceutical industry

Method used

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  • Novel piracetam drug co-crystal and preparation method thereof
  • Novel piracetam drug co-crystal and preparation method thereof
  • Novel piracetam drug co-crystal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Synthesis of co-crystals using piracetam and p-hydroxybenzoic acid:

[0025] Weighing: The reactant is fed with 20.00 mg of piracetam and 20.00 mg of p-hydroxybenzoic acid. Accurately weigh 20.00 mg of piracetam and 20.00 mg of p-hydroxybenzoic acid with an analytical balance.

[0026] Dissolution of the raw material drug: Use a 5ml pipette to accurately measure 4ml of methanol into a 20ml transparent glass vial container, stir for 1 hour to dissolve all the solids, and the solution becomes a colorless clear liquid.

[0027] Solvent room temperature volatilization heating method: After the solid is completely dissolved, take out the stirring bar, seal the bottle mouth with tin foil, prick a few small holes with a needle, and let it stand for volatilization. After about 6 days, colorless transparent block crystals precipitated in the bottle.

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PUM

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Abstract

The invention belongs to the technical field of drug co-crystals and in particular relates to a novel piracetam drug co-crystal and a preparation method thereof. An N atom on an amino group in one piracetam molecule is taken as a hydrogen bond donor, an O atom on a p-hydroxybenzoic acid carboxyl is taken as a hydrogen bond acceptor, and the N atom and the O atom form a basic structural unit of the piracetam co-crystal by forming hydrogen bonds. The preparation method of the piracetam drug co-crystal is a solvent room temperature volatilization method. The drug co-crystal prepared by the invention inherits the characteristic of the traditional bulk drug of treating cerebral injury and cerebrovascular diseases, and is obviously improved in the aspects of dissolubility, stability and bioavailability.

Description

technical field [0001] The invention belongs to the technical field of drug co-crystals, and in particular relates to a novel piracetam co-crystal and a preparation method thereof. Background technique [0002] In 1894, E. Fischer of Germany proposed the "lock-key" model based on the idea of ​​"selective interaction between molecules", which was the prototype of modern supramolecular science theory. In 1937, German K. L. Wolf created the term "supramolecule" to describe highly ordered entities formed by the association of molecules. In a general sense, any collection of molecules has interactions, so people often refer to them as The structural level of matter aggregation state is called "supramolecular". It was not until 1978 that Professor J. M. Lehn of France finally proposed the complete concept of "supramolecular chemistry" based on the traditional research on the host-guest system rooted in organic chemistry. Supramolecular chemistry is a science that studies complex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/27
Inventor 罗亚楠曹雪玲于晓洋连丽丽曲晓姝张伟李佳
Owner JILIN INST OF CHEM TECH
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