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Doxofylline capsule and preparation method thereof

A technology of doxofylline and capsules, which is applied in the field of pharmaceutical preparations, can solve the problems of complex preparation process of freeze-dried preparations, increase of patient treatment costs, and high production costs, and achieve the effects of low production costs, fast dissolution speed, and increased fluidity

Inactive Publication Date: 2013-04-24
四川健能制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The function of doxofylline to dilate the bronchi clinically requires doxofylline to exert its drug effect as quickly as possible. Therefore, the current marketed dosage forms of doxofylline are mainly freeze-dried preparations, which have the characteristics of fast onset of action. However, the preparation process of freeze-dried preparations is complicated, and the production cost is high, which increases the treatment cost of patients.

Method used

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  • Doxofylline capsule and preparation method thereof
  • Doxofylline capsule and preparation method thereof
  • Doxofylline capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Prescription (Specification: 0.2g)

[0016]

[0017] craft

[0018] (1) Requirements for the particle size of raw and auxiliary materials: the particle size of doxofylline is less than 250 microns, and the amount of doxofylline with a particle size of less than 106 microns accounts for no more than 10% of the total amount of doxofylline by weight; The particle size is less than 150 microns, wherein the amount of precrossified starch with a particle size of less than 106 microns accounts for no more than 5% by weight of the total amount of precrossed starch; the particle size of magnesium stearate is a conventional requirement;

[0019] (2) Mixing: take the doxofylline, pregelatinized starch, and magnesium stearate of the prescription amount and add them to the two-dimensional motion mixer, and the mixing time is 25 minutes to obtain the total mixture;

[0020] (3) Filling: Calculate the theoretical grain weight according to the percentage of the blend and the specif...

Embodiment 2

[0028] Prescription (Specification: 0.2g)

[0029]

[0030] craft

[0031] (1) Requirements for the particle size of raw and auxiliary materials: the particle size of doxofylline is less than 250 microns, and the amount of doxofylline with a particle size of less than 106 microns accounts for no more than 10% of the total amount of doxofylline by weight; The particle size is less than 150 microns, wherein the amount of precrossified starch with a particle size of less than 106 microns accounts for no more than 5% by weight of the total amount of precrossed starch; the particle size of magnesium stearate is a conventional requirement;

[0032] (2) Mixing: the doxofylline, pregelatinized starch, and magnesium stearate of the prescribed amount are weighed and added to a two-dimensional motion mixer, and the mixing time is 35 minutes to obtain a total mixture;

[0033] (3) Filling: Calculate the theoretical grain weight according to the percentage of the blend and the specific...

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Abstract

The invention discloses a doxofylline capsule and a preparation method of the doxofylline capsule. The doxofylline capsule comprises the following components in percentage by weight: 85-90% of doxofylline, 5-14% of pregelatinized starch and 0.1-1% of magnesium stearate. The doxofylline capsule is high in main drug content, little in dosage of accessory varieties and high in dissolution rate.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to a pharmaceutical composition, in particular to a doxofylline capsule and a preparation method thereof. Background technique [0002] Doxofylline (Doxofylline) is a phenoline drug, its chemical name is 1,3-dimethyl-7-(1,3-dioxol-2-yl)methyl-3,7-di Hydrogen-1H-purine-2,6-dione is a derivative of xanthine. It has the functions of antitussive, asthmatic and bronchial dilation. Its drug effect is 10-15 times that of similar drug aminophylline, non-addictive, and has no side effects on the central nervous system and cardiovascular system. [0003] The function of doxofylline to dilate the bronchi clinically requires doxofylline to exert its drug effect as quickly as possible. Therefore, the currently marketed dosage forms of doxofylline are mainly freeze-dried preparations, which have the characteristics of fast onset of action. However, the preparation process of the freeze-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/522A61P11/06A61P11/14A61P11/08
Inventor 王国华胡延贵梅勇王进涛傅启昌李侠刘萍
Owner 四川健能制药有限公司