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Novel leonurus capsule and preparation method thereof

A technology of motherwort and motherwort extract is applied in the directions of capsule delivery, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc. Easy production and processing, high clinical effect, reasonable selection of excipients

Active Publication Date: 2013-05-01
SHENYANG YONGDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1. Deliquescence and adhesion often occur in the contents of the capsule, which makes the production and processing difficult and the qualified rate of the finished product is low;
[0004] 2. The selection of auxiliary materials is unreasonable;
[0005] 3. Improper preparation process of motherwort extract leads to low transfer rate of stachydrine hydrochloride and motherurine hydrochloride, requiring more reasonable and precise preparation methods

Method used

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  • Novel leonurus capsule and preparation method thereof
  • Novel leonurus capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Motherwort Capsules (0.35g per capsule)

[0052] Prescription: motherwort 16670g starch 1530g

[0053] Preparation method: Take 16670g of motherwort, chop it, add water and decoct three times, add 12 times the amount of water for the first time, decoct for 1 hour, add 10 times and 8 times the amount of water for the second and third times, decoct 1 hours, combined the decoctions, filtered, and concentrated the filtrate to obtain 8330ml of a concentrated solution with a relative density of 1.14-1.18 measured at 60-70°C, let it cool, added 8330ml of ethanol, stirred well, stood for 12 hours, filtered, and used for the filter residue Wash with 45% ethanol, absorb the liquid and combine the filtrate, recover the ethanol under reduced pressure, concentrate the remaining liquid to a thick paste, add 1530g of starch, mix well, dry at 60-80°C, crush, sieve, pack into capsules, and make 10,000 capsules. Instantly.

Embodiment 2

[0054] Example 2 Motherwort Capsules (0.35g per capsule)

[0055] Prescription: motherwort 14500g starch 1700g (containing 44% amylose and 37% amylopectin)

[0056] Preparation method: Take 14500g of motherwort, chop it, add water to decoct three times, add 12 times the amount of water for the first time, decoct for 1 hour, add 10 times and 8 times the amount of water for the second and third times, decoct 1 hours, combined the decoctions, filtered, and concentrated the filtrate to obtain 9000ml of a concentrated solution with a relative density of 1.14-1.18 measured at 60-70°C. Let it cool, add 9000ml of ethanol, stir well, let stand for 12 hours, filter, and use the filter residue Wash with 45% ethanol, absorb the liquid and combine the filtrate, recover the ethanol under reduced pressure, concentrate the remaining liquid to a thick paste, add 1700g of starch, mix well, dry at 60-80°C, crush, sieve, pack into capsules, and make 10,000 capsules. Instantly.

Embodiment 3

[0057] Example 3 Motherwort Capsules (0.35g per capsule)

[0058] Prescription: motherwort 1850g, starch 130g (including 30g modified starch and 100g unmodified starch)

[0059] Preparation method: Take 1667g of motherwort, chop it, add water to decoct three times, add 12 times the amount of water for the first time, decoct for 1 hour, add 10 times and 8 times the amount of water for the second and third times, and decoct 1 hours, combined the decoctions, filtered, and concentrated the filtrate to obtain 833ml of a concentrated solution with a relative density of 1.14-1.18 measured at 60-70°C, let it cool, added 833ml of ethanol, stirred well, stood for 12 hours, filtered, and used the filter residue Wash with 45% ethanol, absorb the liquid and combine the filtrate, recover the ethanol under reduced pressure, concentrate the remaining liquid to a thick paste, add 130g of starch, mix well, dry at 60-80°C, crush, sieve, pack into capsules, and make 1000 capsules. Instantly.

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Abstract

The invention relates to a novel leonurus capsule which comprises a capsule shell and a content mounted in the capsule shell, wherein the content comprises a leonurus extract and starch, and the weight part ratio of leonurus to the starch for preparing the leonurus extract is (1350-1950):(100-200). Due to optimal proportioning of the leonurus and the starch and with the adoption of the starch, an ideal curative effect is achieved, clinical trials show that a total integral of a treatment group is 4.1-8.12 and a total integral of a control group is 5.9-9.08, and the leonurus capsule and a Bazhenyimu capsule have significant difference (P less than 0.05) in improving metrorrhagia, uterus meromorphosis and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a novel motherwort capsule and a preparation method thereof. Background technique [0002] Motherwort Capsules are drugs approved by the State Food and Drug Administration of China for the treatment of uterine contractions. They are mainly used for regulating menstruation, postpartum uterine bleeding, and incomplete uterine recovery. In addition, Chinese patent CN1569130A discloses a water extract of motherwort, and a capsule of motherwort can be prepared from the water extract. At present, the main problems of motherwort capsules are: [0003] 1. Deliquescence and adhesion often occur in the contents of the capsule, which makes the production and processing difficult and the qualified rate of the finished product is low; [0004] 2. The selection of auxiliary materials is unreasonable; [0005] 3. Improper preparation process of motherwort extract leads...

Claims

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Application Information

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IPC IPC(8): A61K36/533A61K47/36A61K9/48A61P15/00A61P15/04
Inventor 彭宣玮邹洪君
Owner SHENYANG YONGDA PHARMA
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