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Method for extracting DNJ (Deoxynojirimycin) from frosted mulberry leaf by fermenting

A technology of frost mulberry leaf and fermentation method, which is applied in the field of DNJ extraction from frost mulberry leaf by fermentation method, and achieves the effects of low preparation cost, no chemical pollution and simple process

Inactive Publication Date: 2013-05-01
李哲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the equipment and technology involved in the current extraction methods are by no means suitable for the conditions of general enterprises.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0007] The following are examples of the present invention.

[0008] Choose the late autumn frost mulberry leaves from the mulberry planting area in Luliang, Yunnan Province as raw materials, wash them with clean water, dry the surface moisture of the leaves, and then pile them up. The accumulation amount of each pile is determined according to the area size of the covering film. The surrounding area of ​​the mulberry leaf pile should also be set to facilitate the terrain treatment of sealing coverage. In order to ensure the temperature, physical heating and cooling conditions can be adopted, and the site is also chosen to be in a well-sealed room that is convenient for heat preservation. The cover film adopts a transparent film to facilitate the observation of the fermentation situation, such as the time for mycelia to grow and all leaves to grow mycelium.

[0009] When the fermented mulberry leaf mycelium grows into a cake, the covering film can be uncovered, and the fermen...

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PUM

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Abstract

The invention discloses a method for extracting DNJ (Deoxynojirimycin) from frosted mulberry leaf by fermenting. The method is characterized by comprising the following steps of: cleaning the frosted mulberry leaf serving as a raw material, natural airing moisture on the surface, piling on the ground; covering with a packing food-level plastic film, piling and fermenting in an environment where the temperature does not surpass 30-50 DEG C till mycelia grow from all leaves, drying at the temperature of not higher than 65 DEG C, and loading into a cloth bag; soaking again; and extracting through extracting equipment according to a method combining ultrasonic waves and microwaves to obtain DNJ. According to the method, any organic solvent is not used, so that chemical pollution is avoided; and a process is simple, and the preparation cost is low.

Description

technical field [0001] The invention relates to a fermentation method for extracting DNJ from frost mulberry leaves. Background technique [0002] Deoxynojirimycin (1-deoxynojirimycin, DNJ) is a structural analogue of natural sugar. Modern pharmacological studies have shown that DNJ is a highly effective α-glucosidase inhibitor with good hypoglycemic activity and broad application prospects. At present, the main ways to obtain DNJ are natural sources and chemical synthesis, but the existing chemical synthesis methods have disadvantages such as complex processes, harsh conditions, and low yields. Therefore, obtaining high-purity DNJ from natural products has become a research hotspot today. Modern research has found that a variety of plants and microorganisms contain DNJ, but one of them has the highest content in mulberry leaves. Among the mulberry leaves, autumn mulberry leaves are the most effective. According to the introduction of relevant medical books, frost mulberr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D211/46
Inventor 李哲李国强
Owner 李哲