Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Roseburia to treatment and prevention of obesity related disease

A Rosella, purpose-built technology for use in microbiology that solves problems of expensive, miscalculated, immune-resistance

Active Publication Date: 2015-03-04
SHENZHEN HUADA GENE INST +1
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For patients, the use of exogenous insulin is an expensive and painful method, and it also brings many complications to the patient
Insulin response (hypoglycemia) due to miscalculation of insulin doses, for example, due to missing meals or erratic exercise
In addition, local or systemic allergy or immune resistance to the drug may occur with the use of the drug
[0006] At present, there is no effective method and medicine for the treatment and prevention of obesity and related diseases with little side effects in this field, so there is an urgent need in this field to develop a new, non-toxic and side effect drug for the treatment and prevention of obesity and obesity. Drugs for its related diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Roseburia to treatment and prevention of obesity related disease
  • Application of Roseburia to treatment and prevention of obesity related disease
  • Application of Roseburia to treatment and prevention of obesity related disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Experimental Materials

[0069] Mice: C57BL / 6J mice (purchased from the Experimental Animal Center of Southern Medical University) were purchased, which were normally raised mice, 6 weeks old, with a total of 15 mice. Mice were grown in the same environment and fed the same food.

[0070] Strain: Roseburia inulinivorans DSM 16841 strain, purchased from DSMZ (Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH).

[0071] High-fat food (HF): 58% lard, 25.6% carbohydrate, 16.4% protein, purchased from Beijing Huafukang Biotechnology Co., Ltd.

[0072] Conventional mouse chow: purchased from the Animal Experiment Center of Southern Medical University.

Embodiment 2

[0074] Mice grouping and induction treatment

[0075] In this example, a total of 3 experimental groups were set, with 5 animals in each group.

[0076] 6-week-old C57BL / 6J mice that were normally fed (without sterility) were selected for the experiment. The Rothella DSM 16841 bacteria to be tested were introduced into the intestinal tract of mice by feeding method, and the insulin resistance ability of mice was identified by glucose tolerance (OGGT) test.

[0077] For specific experimental grouping information and processing steps, see figure 1 .

[0078] The 15 repurchased mice were kept in the same environment until 6 weeks of age (the food did not need to be sterilized), the feeding amount was recorded, and the weight change and physical condition of the mice were regularly monitored.

[0079] The 15 mice were equally divided into 3 experimental groups (5 mice in each experimental group), placed in the ultra-clean workbench, and officially entered the experimental period....

Embodiment 4

[0084] Experimental results:

[0085] 1. The results of body weight gain of mice fed for 10 weeks are shown in Table 1 and figure 2 .

[0086] Table 1

[0087]

[0088] 2. The results of the comparison of the P value of the difference in body weight gain of the mice fed for 10 weeks are shown in Table 2 and image 3 .

[0089] Table 2

[0090]

[0091] From Table 1, Table 2 and figure 2 , image 3 It can be seen that feeding the test bacteria for 10 weeks can significantly reduce the body weight of obese mice.

[0092] 3. The measurement results of blood glucose content in the 10th week of feeding are shown in Table 3, Table 4 and Figure 4 , Figure 5 .

[0093] table 3

[0094] grouping

[0095] 1.

[0096] Table 3 and Figure 4 It is shown that feeding the test bacteria can significantly reduce the blood sugar of obese mice.

[0097] Table 4

[0098] P value

[0099] Table 4 and Figure 5 It was shown that feeding the te...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present disclosure provides a use of Roseburia in the preparation of composition for prevention and / or treatment of obesity related diseases. Also provided are a composition used in the treatment and prevention for obesity related diseases, comprising pharmaceutical, drink, food, or animal feed composition, etc; and a method of reducing body weight and / or blood glucose.

Description

technical field [0001] The present invention belongs to the field of microbiology, in particular, the present invention relates to the application of Roseburia in the treatment and prevention of obesity-related diseases, and also relates to a composition comprising Roseburia and its application. Background technique [0002] Obesity is a chronic disease, many factors can lead to obesity, and its origin has not been clearly studied. Obesity is also an inducing factor of a series of diseases, such as hypertension, diabetes, coronary heart disease, gallbladder disease, osteoarthritis, sleep apnea, breathing disorders, uterine tumors, prostate cancer, breast cancer and colon cancer. According to the NHI report, about 97 million Americans are currently overweight and obese, of which about 15.1 million are obese-related type 2 diabetes, and about 200,000 people die each year from obesity-related diseases. [0003] Obesity is usually an excess of body fat due to altered physiologi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/30A23L2/52A23K1/16A61K35/74A61P3/04A61P3/10
CPCC12N1/20A23V2002/00A23L1/3014A61K9/19A61K35/74A23L33/135A61P3/04A61P3/10Y02A50/30
Inventor 覃俊杰冯强李胜辉朱剑锋李晓平梁穗莎王俊汪建杨焕明
Owner SHENZHEN HUADA GENE INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com