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Catechin applied in detoxification body intaking PAEs type environmental endocrine disruptor

An endocrine disruptor, catechin technology, applied in the pharmaceutical field, can solve problems such as unreported

Inactive Publication Date: 2013-05-22
CHINA JILIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that catechins have multiple functions in the prevention and treatment of cardiovascular diseases and cancer, but there is no report on the efficacy of detoxifying the body's intake of PAEs environmental endocrine disruptors

Method used

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  • Catechin applied in detoxification body intaking PAEs type environmental endocrine disruptor
  • Catechin applied in detoxification body intaking PAEs type environmental endocrine disruptor
  • Catechin applied in detoxification body intaking PAEs type environmental endocrine disruptor

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Embodiment Construction

[0011] The invention relates to a method of using catechin to detoxify the body to ingest PAEs environmental endocrine disruptors, which are illustrated by the following experimental examples.

[0012] 1 Materials and methods

[0013] 1.1 Materials

[0014] 1.1 Experimental animals

[0015] Male mice (ICR) were purchased from the Experimental Animal Center of Hangzhou Normal University.

[0016] 1.2 Reagents

[0017] Hematoxylin and eosin were purchased from Zhuhai Beso Biotechnology Co., Ltd.; Giemsa dye was purchased from Shanghai Sangon Bioengineering Co., Ltd.; fluorescent dye Rh123, FITC-labeled goat anti-rabbit secondary antibody, and rabbit anti-aromatase polyclonal antibody were purchased from Santa Cruz; Embedded paraffin was purchased from Leica; immunohistochemical kits were purchased from Beijing Zhongshan Jinqiao Biotechnology Co., Ltd.; cyclophosphamide (CP) was purchased from Shanghai Second Pharmaceutical Factory; dimethyl phthalate (DMP), phthalate Diethyl...

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Abstract

The invention relates to a catechin applied in detoxification body intaking PAEs type environmental endocrine disruptor. Prepared into an oral solution and taken orally, the catechin disclosed by the invention has the advantages of good curative effect for the detoxification body intaking PAEs type environmental endocrine disruptor and good application prospect. Moreover, the dosage of the catechin is 10-50mg / kg.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to the new application of catechin in detoxifying the body to ingest PAEs environmental endocrine disruptors. Background technique [0002] Catechin and its oxidation products are carbon-hydrogen-oxygen ternary compounds, which are synthesized from sugars through a series of enzymes to form benzene ring compounds through the shikimic acid pathway, and finally synthesized into catechins. Catechin is an important component of tea, accounting for about 75% to 80% of the content of tea polyphenols, and is also one of the sources of tea's bitter taste. Catechin has obvious phenolic properties, can precipitate heavy metals and proteins, is easily oxidized by air in aqueous solution, and is often used as an antioxidant. It has been reported that catechins have multiple functions in the prevention and treatment of cardiovascular diseases and cancer, but there is no report on the efficac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P39/02
Inventor 胡华军胡天宇葛建王敏君姚元发韩宝瑜屈叶青王慧杨丛军袁萍李燕冷贞贞刘晓菲
Owner CHINA JILIANG UNIV