Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and preparation method

A new technology of composite microspheres and thymus method, which is applied in the field of medicine, can solve the problems of poor stability of preparations and require refrigerated storage, and achieve the effect of simple and feasible preparation process, good reproducibility, good market and application prospects

Active Publication Date: 2014-08-20
GUANGDONG XIANQIANG PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a new thymus method new chitosan / β-cyclodextrin composite microspheres for the short half-life of the thymus method, which needs multiple administrations in a short time, and the poor stability of the preparation requires refrigerated storage. medicine system

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and preparation method
  • Thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and preparation method
  • Thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Weigh 0.2g of chitosan powder and disperse it in 10mL, 2% acetic acid aqueous solution, fully dissolve, let stand to drain the air bubbles to obtain chitosan acetic acid aqueous solution; weigh 1g of β-cyclodextrin into the reaction bottle, add 20mL to Ionized water, mechanically stirred (can be properly heated) to dissolve completely, to obtain an aqueous solution containing β-cyclodextrin; slowly add chitosan acetic acid aqueous solution to the aqueous solution containing β-cyclodextrin, stir evenly, as the water phase; Add 60mL liquid paraffin, 1.8mL span-80 and 0.3g dispersant magnesium stearate to another reaction bottle to form the oil phase; slowly add the water phase to the oil phase, stir until the solution is emulsified and dispersed into beads of appropriate size , slowly drop into 0.5mL 25% glutaraldehyde (cross-linking agent) solution to cross-link and solidify, stir rapidly, collect the precipitate after 2 hours, filter with suction, wash repeatedly with pe...

Embodiment 2

[0049] Weigh 0.6g of chitosan powder and disperse it in 10mL, 2% acetic acid aqueous solution, fully dissolve, let stand to drain out the air bubbles, and obtain chitosan acetic acid aqueous solution; weigh 0.6g of β-cyclodextrin into the reaction bottle, add 20mL Deionized water, mechanical stirring (can be properly heated) to dissolve completely, to obtain an aqueous solution containing β-cyclodextrin; slowly add chitosan acetic acid aqueous solution to the aqueous solution containing β-cyclodextrin, stir evenly, as the water phase; In another reaction bottle, add 120mL of a mixture of liquid paraffin and petroleum ether, 6mL of span-80 and 1g of dispersant magnesium stearate to form the oil phase; slowly add the water phase into the oil phase, stir until the solution is emulsified and dispersed to a suitable size Add 2.5mL of 25% glutaraldehyde (cross-linking agent) solution to cross-link and solidify, collect the precipitate after 2h, wash repeatedly with isopropanol three ...

Embodiment 3

[0053] Weigh 0.15g of chitosan powder and disperse it in 10mL, 2% acetic acid aqueous solution, fully dissolve, let stand to drain out the air bubbles, and obtain chitosan acetic acid aqueous solution; weigh 1.5g of β-cyclodextrin into the reaction bottle, add 20mL of deionized water, mechanically stirred (can be properly heated) to dissolve completely, to obtain an aqueous solution containing β-cyclodextrin; slowly add chitosan acetic acid aqueous solution to the aqueous solution containing β-cyclodextrin, stir evenly, as the water phase ;Add 30mL liquid paraffin, 15mL span-80 and 1.5g dispersant magnesium stearate to another reaction bottle to form the oil phase; slowly add the water phase to the oil phase, stir until the solution is emulsified and dispersed into beads of suitable size Add 0.6 mL of 25% glutaraldehyde (cross-linking agent) solution to cross-link and solidify. After 2 hours, the precipitate is collected, washed three times with ethanol, and dried to obtain emp...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a novel thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and a preparation method. Chitosan serves as a membrane material, beta-cyclodextrin serves as a clathration material, and a composite microsphere is prepared in a reversed phase suspension-chemical crosslinking method. According to the novel thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system, the composite microsphere carries thymalfasin. According to the novel thymalfasin drug delivery system, the obtained composite microsphere performs good protection and controlled-release functions on the thymalfasin, provides feasibility for oral administration medicines and has good economic benefits and application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a novel thymus-process new chitosan / beta-cyclodextrin composite microsphere drug delivery system and a preparation method. Background technique [0002] Thymalfasin (Thymalfasin) is the main component of thymosin component 5 (T5). It is an acidic polypeptide acetylated at the N-terminus. It consists of 28 amino acid residues. Its relative molecular mass is 3108.3 and its isoelectric point is 4.2. Chemically synthesized commodity, its activity is 10-1000 times that of T5, which is a biological response regulator, which can promote the T cell maturation of peripheral blood lymphocytes activated by mitogens, and increase the ability of T cells to respond to various antigens or mitogens. After activation, various lymphokines are produced. [0003] Thymofasin has two main functions: on the one hand, it has immune regulation ability, and on the other hand, it has antivira...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K38/22A61K47/40A61K47/36A61K39/39A61P31/12A61P31/18A61P35/00A61P31/14A61P31/20A61P37/04
Inventor 王学文李玲梅张志生孙晔杜丽丽陈超于云龙
Owner GUANGDONG XIANQIANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com