Method for preparing collagen/lactic acid-caprolactone copolymer composite fiber bracket

A collagen and composite fiber technology, applied in the fields of medical science, textiles and papermaking, prostheses, etc., can solve the problem of not fully meeting the requirements of cell growth, and achieve the effect of promoting cell growth.
CN103147229AActive Publication Date: 2013-06-12DONGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DONGHUA UNIV
Publication Date
2013-06-12

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Abstract

The invention relates to a method for preparing a collagen / lactic acid-caprolactone copolymer composite fiber bracket. The method comprises the following steps of: (1) dissolving collagen into hexafluoroisopropanol, uniformly stirring to obtain a collagen solution with the concentration of 4 to 10 percent (g / ml), dissolving lactic acid-caprolactone copolymer into the hexafluoroisopropanol, and uniformly stirring to obtain a lactic acid-caprolactone copolymer solution with the concentration of 4 to 10 percent (g / ml); (2) mixing the collagen solution with the lactic acid-caprolactone copolymer solution to obtain a blended electrostatic spinning solution, wherein the volume ratio of the total solute to a solvent is 4 percent to 10 percent; and (3) performing electrostatic spinning on the blended electrostatic spinning solution to obtain the collagen / lactic acid-caprolactone copolymer composite fiber bracket. The aperture of the prepared bracket is increased along with the increase of fiber diameter. The bracket has the structural characteristics of nano- and micro-fibers, simulates an extracellular matrix, and has a great application prospect.
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Description

technical field

[0001] The invention belongs to the field of preparation of composite fiber scaffolds, in particular to a preparation method of collagen / lactic acid-caprolactone copolymer composite fiber scaffolds. Background technique

[0002] The core of tissue engineering is to construct a three-dimensional space complex composed of biomaterials and cells, that is, tissue engineering scaffold composite seed cells. Its biggest advantage is that it can form living tissues with vitality, bionic human tissues and organs, reconstruct the shape, structure and function of damaged tissues and achieve permanent replacement; use less tissue cells to complete the repair and repair of damaged tissues. regeneration. In this process, tissue engineering scaffolds provide an appropriate microenvironment for cell growth and migration, including adhesion sites and growth signals.

[0003] Tissue engineering scaffold is one of the key factors to determine the success of tissue repair. An...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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