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Use of effective components of Clausena lansium for treating neurodegenerative diseases

A neurodegenerative and disease-related technology, applied to medical preparations containing active ingredients, nervous system diseases, organic active ingredients, etc., can solve problems such as unstable curative effect, unclear mechanism of action, and unclear active ingredients

Inactive Publication Date: 2013-06-26
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition of traditional Chinese medicine is complex, the active ingredients are not clear, the curative effect is unstable, and the mechanism of action is not clear, which seriously affects the clinical use and the entry of Chinese medicine into the international mainstream market. Drugs for the treatment of degenerative diseases are an urgent task for medical researchers for a long time to come

Method used

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  • Use of effective components of Clausena lansium for treating neurodegenerative diseases
  • Use of effective components of Clausena lansium for treating neurodegenerative diseases
  • Use of effective components of Clausena lansium for treating neurodegenerative diseases

Examples

Experimental program
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Effect test

experiment example 1

[0041] Experimental example 1: Effect of the compound of the present invention on the survival state of rat cerebral cortex neurons and its protective effect in the model of neuron apoptosis induced by sodium nitroprusside

[0042] In the study of the effect of the compound on the survival state of neurons, the primary cultured rat cortical neurons (DIV-9) were divided into a control group and an administration group (10 μM), n=6; In the study of the protective effect of the apoptosis model, the primary cultured rat cortical neurons (DIV-7) were divided into the control group, the sodium nitroprusside (350 μM) model group, and the sodium nitroprusside (350 μM) + edaravone ( 100 μM) administration group, sodium nitroprusside (350 μM)+compound (10 μM) administration group, n=6. After administration, the cells were placed in a cell incubator to continue culturing for 24 hours, and the cell viability was measured by the MTT method (570 nm). Taking the absorbance of the control gr...

experiment example 2

[0051] Experimental Example 2: The protective effect of the compound on glutamate-induced apoptosis of rat cortical neurons

[0052]The primary cultured rat cortical neurons (DIV-9) were divided into control group, glutamate (20mM) modeling group, glutamate (20mM)+edaravone (100μM) administration group, glutamate (20 mM)+compound (10 μM) administration group, n=6, after continuing to culture in the cell incubator for 24 hours, the cell viability was measured by MTT method. Taking the absorbance of the control group as the standard, the ratio of the absorbance of each group to the control group was calculated.

[0053] Table 2 Effects of Compounds on Glutamate-Induced Apoptosis of Rat Cortical Neurons

[0054]

[0055]

[0056] Note: The survival rate is expressed as Mean±S.E.M

[0057] ###P** P* P<0.05vs glutamate model group.

[0058] The experimental results showed that after glutamate modeling, the survival rate of neurons was significantly reduced, while the survi...

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Abstract

The invention discloses use of effective components of Clausena lansium for treating neurodegenerative diseases. The effective components seven carbazole alkaloids of Clausena lansium (lour.)skeels are shown in the specification. The invention further discloses a preparation method of the seven carbazole alkaloids as well as application thereof in preparing medicines for treating neurodegenerative diseases, in particular stroke or stupid.

Description

technical field [0001] The invention relates to a preparation method of seven carbazole alkaloids (1-7) as effective components of Clausena lansium (lour.) skeels, and their application in the preparation of drugs for treating neurodegenerative diseases. Background technique [0002] Clausena lansium (lour.) skeels is a Clausena plant of Rutaceae Rutaceae. It is mainly produced in southern my country. It is widely planted in Fujian, Guangdong, Taiwan, Guangxi, Yunnan and other places. Its roots, branches, leaves, fruits and The seeds are used as medicine. The nature and flavor of the branches and leaves of the yellow bark belong to Xinliang (Luchuan Materia Medica). [0003] As my country's aging society accelerates, the number of elderly people continues to increase. According to statistics, by 2020, my country's aging level will reach 17.17%, and the number of patients with various geriatric diseases is also on the rise. In developed countries, stroke and Alzheimer's dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/403A61P25/28A61P9/10A61P25/00A61P39/02C07D209/86C07D209/88
Inventor 陈乃宏张东明宁娜柳航
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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