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Hypolipidemic traditional Chinese medicine composition and preparation method and application thereof

A composition and blood lipid-lowering technology, which are applied in the field of medicine containing the Chinese medicine composition, blood-lipid-lowering Chinese medicine composition and its preparation field, can solve the problem that the effective part and active ingredient are not clear, and it is difficult to meet the requirements of safety, effectiveness and controllability of traditional Chinese medicine. , stability, poor controllability of quality standards, etc.

Active Publication Date: 2013-07-03
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the effective parts and active ingredients of Alisma Decoction for lowering blood lipids are still unclear, which limits its application. In addition, the water decoction of Alisma Decoction is often used clinically, which is inconvenient to carry and use, and the quality standard is poorly controllable. Meet the requirements of "safety, effectiveness, controllability and stability" of traditional Chinese medicine

Method used

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  • Hypolipidemic traditional Chinese medicine composition and preparation method and application thereof
  • Hypolipidemic traditional Chinese medicine composition and preparation method and application thereof
  • Hypolipidemic traditional Chinese medicine composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] This example is used to illustrate the traditional Chinese medicine composition of the present invention and its preparation method and application.

[0071] Weigh 10kg of Alisma and 10kg of Atractylodes macrocephala and mix them, use four times the amount of 90% ethanol aqueous solution to extract twice, each time for 1.5h, combine the extracts, filter, concentrate the supernatant until it has no alcohol smell, and use 10L wet The HPD-100 type macroporous adsorption resin is used for adsorption, washed with 40L of water and 40L of 30% ethanol aqueous solution in sequence, and then eluted with 60% ethanol aqueous solution, the eluate is collected and concentrated, and dried under reduced pressure, namely Deze Extract of a mixture of Laxative and Atractylodes Rhizoma. In the above-mentioned concentration operation, ethanol can be recovered and reused at the same time. The extract can be directly used as the traditional Chinese medicine composition of the present inventi...

Embodiment 2

[0075] This example is used to illustrate the traditional Chinese medicine composition of the present invention and its preparation method and application.

[0076] Weigh 10 kg of Alisma and 1 kg of Atractylodes Rhizome and mix them, use four times the amount of 95% ethanol aqueous solution to extract twice, each time for 2 hours, combine the extracts, filter, concentrate the supernatant until there is no alcohol smell, and use 10L wet HPD-300 type macroporous adsorption resin is adsorbed, washed with 40 L of water and 40 L of 50 volume % ethanol aqueous solution successively, then eluted with 85 volume % ethanol aqueous solution, the eluate is collected and concentrated, and dried under reduced pressure to obtain Alisma and the extract of the mixture of Atractylodes macrocephala. In the above-mentioned concentration operation, ethanol can be recovered and reused at the same time. The extract can be directly used as the traditional Chinese medicine composition of the present ...

Embodiment 3

[0080] This example is used to illustrate the traditional Chinese medicine composition of the present invention and its preparation method and application.

[0081] Weigh 1 kg of Alisma and 10 kg of Atractylodes Rhizome and mix them, use four times the amount of 80% ethanol aqueous solution to extract three times, each time for 1 hour, combine the extracts, filter, concentrate the supernatant until there is no alcohol smell, and use 10L wet D101 type macroporous adsorption resin for adsorption, followed by washing with 40L of water and 40L of 60% by volume ethanol aqueous solution, and then eluting with 90% by volume of ethanol aqueous solution, collecting the eluate and concentrating, drying under reduced pressure to obtain Alisma and Atractylodes macrocephala Mixture of extracts. In the above-mentioned concentration operation, ethanol can be recovered and reused at the same time. The extract can be directly used as the traditional Chinese medicine composition of the present...

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Abstract

The invention provides a hypolipidemic traditional Chinese medicine composition, and a preparation method and an application thereof. The traditional Chinese medicine composition comprises an extract of a mixture of oriental waterplantain tuber and largehead atractylodes rhizome. The composition is characterized in comprising 0.5-2wt% of 23-acetyl alisol B and 0.1-1wt% of atractylenolide B. The invention also provides a preparation method of the traditional Chinese medicine composition, an application of the traditional Chinese medicine composition in preparing hypolipidemic medicines, and medicines comprising the traditional Chinese medicine composition.

Description

technical field [0001] The present invention relates to a Chinese medicine composition and its preparation method and application, in particular to a blood lipid-lowering Chinese medicine composition and its preparation method, and the application of the Chinese medicine composition in the preparation of blood lipid-lowering medicine and containing the Chinese medicine composition drug. Background technique [0002] According to WHO estimates, cardiovascular and cerebrovascular diseases are currently the most threatening diseases to human beings. Cardiovascular and cerebrovascular diseases cause at least 12 million deaths worldwide every year, and have become the number one enemy of human health. Among them, coronary heart disease and stroke accounted for 28.8% of the total death toll in the world, ranking first among non-communicable diseases. With the increase of life expectancy, the affluence of material conditions and the change of living and cultural styles, the incide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61P3/06A61P9/10A61K31/58A61K31/365
Inventor 孙卫张铁军廖茂梁龚苏晓郑雅楠
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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