Application of icariin in preparation of medicaments for treating gout

A technology for icariin and gout, which is applied in the field of application of icariin in the preparation of medicines for treating gout, and can solve problems such as no anti-gout

Active Publication Date: 2014-07-23
广西神力制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report of anti-gout

Method used

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  • Application of icariin in preparation of medicaments for treating gout
  • Application of icariin in preparation of medicaments for treating gout
  • Application of icariin in preparation of medicaments for treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1 of the present invention: Take 5 g of icariin, 75 g of medicinal starch, and 20 g of microcrystalline cellulose, dry the medicinal starch, pass through a 120-mesh sieve, and mix with icariin and microcrystalline cellulose. Mix, pass through a 120-mesh sieve twice, and fill in hard capsules to make 1000 capsules of the present invention. Each hard capsule contains 0.5 mg of the main ingredient.

Embodiment 2

[0062] Example 2 of the present invention: Icariin 5g, hypromellose 6g, sodium starch glycolate 10g, microcrystalline cellulose 8g, lactose 115g, starch 50g, and magnesium stearate 1g; fully combine the main medicine and auxiliary materials After mixing, put it into a high-speed mixer, spray an appropriate amount of water, granulate the granules, and control the moisture content at 3~4%, then press the tablets to make 1000 tablets and coat them with film.

Embodiment 3

[0063] Example 3: Icariin 5g, add 400 ml polyethylene glycol 200 to dissolve it, add an appropriate amount of distilled water to dilute, then add an appropriate amount of sucrose and adjust the volume to 1000 ml, stir, filter, and fill into 10 ml or 20 ml each, sterilized packaging.

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Abstract

The invention discloses the application of icariin in the preparation of anti-gout medicine. The invention adopts icariin as an anti-gout medicine, and it is verified through animal experiments that the prepared medicine composition can prevent and treat gouty arthritis, including acute gouty arthritis and chronic gouty arthritis. The material of the invention has wide sources, is easy to obtain, is simple and easy to be used for preparing medicine, and has good therapeutic effect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of icariin in the preparation of medicines for treating gout. Background technique [0002] Gout is caused by purine metabolism disorder and decreased uric acid excretion, and its incidence is increasing year by year. The incidence rate varies from country to country, and the incidence rate in Asia has gradually increased in the past 10 years. According to foreign data, the incidence of hyperuricemia in adults is as high as 5%, and the prevalence of gout is as high as 0.13%-0.37%. With the continuous improvement of people's living standards in our country, people's diet structure has changed a lot, high in purine, high in protein and high in fat. In the 21st century, gout has become the second largest metabolic disease in humans after diabetes. The clinical features are: hyperuricemia, recurrent episodes of acute arthritis, tophi formation, chronic arthritis and joint d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P19/06
Inventor 龚其海李利生李菲石京山
Owner 广西神力制药有限公司
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