Image rebuilding algorithm of DOT/XCT (diffuse optical tomography/X-ray computer tomography) dual-mode imaging based on boundary element

A dual-mode imaging and image reconstruction technology, which is applied in image analysis, image data processing, image data processing, etc., can solve problems such as reverse problems and morbidity, and achieve stable reconstruction effects

Active Publication Date: 2013-07-24
HUAZHONG UNIV OF SCI & TECH
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Diffuse optical tomography is inherently a nonlinear pro

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  • Image rebuilding algorithm of DOT/XCT (diffuse optical tomography/X-ray computer tomography) dual-mode imaging based on boundary element
  • Image rebuilding algorithm of DOT/XCT (diffuse optical tomography/X-ray computer tomography) dual-mode imaging based on boundary element
  • Image rebuilding algorithm of DOT/XCT (diffuse optical tomography/X-ray computer tomography) dual-mode imaging based on boundary element

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[0025] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0026] The present invention proposes an image reconstruction algorithm for DOT / XCT dual-mode imaging based on boundary elements. First, the tissue boundary provided by XCT is used to introduce boundary elements into boundary elements, and boundary elements are used as the numerical solution of the forward problem, and then the Levenberg-Marquardt algorithm is used to continuously The optical parameters to be reconstructed are optimized and iterated, so that the results of each forward calculation gradually approach the real detection data until a certain termination condition is met, thereby reconstructing the distribution of optical parameters of different organs in the mouse. The specific process is as figure 1 shown. Its main steps are as follows:

[0027] (...

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Abstract

The invention relates to an image rebuilding algorithm of DOT/XCT (diffuse optical tomography/X-ray computer tomography) dual-mode imaging based on a boundary element, and belongs to the technical field of molecular imaging. The method comprises the following steps of on the basis of providing an organization boundary by XCT , using a boundary element algorithm to solve the positive problem of DOT, namely solving the distribution of light flux at the boundary under the condition of known distribution of optical parameters of different organizations; and in the inverse problem, adopting a Levenberg-Marquardt algorithm to rebuild the absorption coefficients and scattering coefficients of different organizations, namely solving the absorption coefficients and scattering coefficients of the different organizations from the detected light flux data through the process of optimizing a non-linear minimum square model. Compared with the traditional rebuilding method based on finite elements, the boundary is utilized to rebuild in the DOT/XCT dual modes, and the rebuilding of the optical parameters of the organizations is more accurate and stable.

Description

technical field [0001] The invention belongs to the technical field of molecular imaging, relates to an algorithm for image reconstruction, in particular to an image reconstruction algorithm for DOT / XCT dual-mode imaging based on boundary elements. Background technique [0002] Diffuse Optical Tomography (Diffuse Optical Tomography, DOT) is a non-invasive, high-sensitivity optical imaging method, which uses the information of diffuse light passing through the tissue combined with the light transmission model of the tissue to reconstruct the tissue body Optical or physiological parameter distribution of a certain fault plane or even three-dimensional space (Schweiger, M., et al., 3D level set reconstruction of model and experimental data in Diffuse Optical Tomography. Optics express, 2010. 18(1): p. 150-164.). Diffusion optical tomography is essentially a nonlinear problem, and its inverse problem is seriously ill-conditioned. In order to improve the accuracy of reconstruct...

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Application Information

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IPC IPC(8): G06T7/00G06T1/00
Inventor 骆清铭邓勇谢文浩龚辉
Owner HUAZHONG UNIV OF SCI & TECH
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