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Application of doxycycline in preparation of medicine for treating thyroid-associated ophthalmopathy

A doxycycline and thyroid technology, applied in the field of medicine, can solve problems such as infection, aggravated congestive heart failure, and expensive molecular biological agents

Inactive Publication Date: 2013-08-21
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that these immunomodulatory agents alone have limited efficacy in the treatment of GO, and molecular biological agents are expensive, and can cause side effects such as infection, gastrointestinal reactions, nervous system demyelination, lupus-like lesions, and aggravated congestive heart failure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Clinical Study of Doxycycline in the Treatment of Moderately Severely Active Thyroid-Associated Ophthalmopathy

[0018] In accordance with GCP, national and local laws, regulations, and organizational requirements, this trial has obtained written permission from the relevant ethics committee / institutional review board.

[0019] The main research steps are as follows:

[0020] 1. Participants

[0021] Inclusion criteria

[0022] (1) Diagnose GO in strict accordance with the internationally recognized typical clinical features: upper eyelid retraction and edema, exophthalmos, eye movement disorders, one or more extraocular muscle fusiform enlargement or orbital fat volume significantly increased as shown by orbital MRI big.

[0023] (2) The first-diagnosed eye with severe disease was in the moderate to severe active stage of GO. The specific standards are as follows:

[0024] a: moderate to severe eye soft tissue swelling

[0025] b: Exophthalmos ≥ 18mm ...

Embodiment 2

[0149] Example 2 Study on the curative effect of different doses of doxycycline on the treatment of thyroid-associated ophthalmopathy

[0150] The therapeutic effects and safety of different doses of doxycycline 40mg / d, 50mg / d, and 100mg / d on GO in the moderate to severe active stage were compared respectively. The test method was the same as in Example 1, and the results are shown in Table 1.

[0151] Table 1 Comparison of the therapeutic effect and safety of different doses of doxycycline on GO

[0152] dosage

Efficient

Incidence of adverse reactions

Recurrence rate

40mg / d

58%

8%

9%

50mg / d

75%

10%

5%

100mg / d

73%

22%

6%

[0153] It can be seen from Table 1 that the dosage of 50 mg / d has the most ideal therapeutic effect on GO, and the adverse reactions and recurrence rates are also low. The effective rate of 40mg / d for GO treatment is lower than that of 50mg / d and 100mg / d, and the adverse ...

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PUM

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Abstract

The invention discloses application of doxycycline in preparation of a medicine for treating thyroid-associated ophthalmopathy. By the application, a novel effect of the doxycycline for treating the thyroid-associated ophthalmopathy is found according to the development of a research on the doxycycline for treating moderately severe thyroid-associated ophthalmopathy; and the doxycycline is a novel effective, safe and economical treating method for the thyroid-associated ophthalmopathy and has great clinical significance.

Description

technical field [0001] The invention belongs to the field of medicine, in particular, the invention relates to the new application of doxycycline in the preparation of medicines for treating thyroid-associated ophthalmopathy. Background technique [0002] Thyroid-associated ophthalmopathy (Graves’ orbitopathy, GO) is the most common orbital disease in adults, accounting for more than 1 / 3 of outpatients with orbital diseases. The pathogenesis of GO is closely related to immune and inflammatory factors. The ocular manifestations are mainly eyelid retraction, conjunctival congestion and edema, exophthalmos and other appearance changes, as well as orbital pain, eye movement disorders, severe diplopia, exposure keratitis, and compressive optic neuropathy, which are common clinical causes. Blind orbital disease. [0003] The purpose of GO treatment is to suppress inflammation, eliminate related symptoms and signs of soft tissue involvement, reduce exophthalmos, avoid exposure ke...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61P27/02
Inventor 梁丹林妙丽
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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