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Purifying process of crude product of caltrop total saponins

A technology for total saponins of Tribulus terrestris and crude products, which is applied in the technical field of purification of total saponins of Tribulus terrestris, and can solve problems such as interference

Active Publication Date: 2014-08-06
SUZHOU GULI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the research, some unknown impurities in the total saponins of Tribulus terrestris prepared by the above method will interfere with the pharmacological research results, resulting in unexplained abnormal results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Take 10g of the crude total saponins of Tribulus terrestris, dissolve it completely with 1.0L of water, add 150ml of 1% acetic acid solution and mix, stir and then add 10g of treated IRP64 resin, conduct ion exchange at a temperature of 25°C and a stirring speed of 300r / min for 1 After standing for 10 minutes, suction filtration, the filtrate was discarded, 85% alcohol was used to elute the filter cake (140ml), and then suction filtration, the eluent and filtrate were combined to recover the alcohol under reduced pressure, and the residue was dried to obtain Tribulus terrestris Refined products of total saponins. The detection content is 98.5%.

Embodiment 2

[0010] Take 00g of crude total saponins of Tribulus terrestris, dissolve it completely with 1.0L of water, add 150ml of 1% acetic acid solution to mix, stir and then add 10g of treated IRP64 resin, carry out ion exchange at a temperature of 25°C and a stirring speed of 300r / min for 2 After standing for 15 minutes, suction filtration, the filtrate was discarded, 85% alcohol was used to elute the filter cake (140ml), and then suction filtration, the eluent and filtrate were combined under reduced pressure to recover the alcohol, and the residue was dried to obtain Tribulus terrestris Refined products of total saponins. The detected content is 98.2%.

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PUM

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Abstract

The invention provides a purifying process of a crude product of caltrop total saponins. Compared with existing resin purifying methods, the process has the advantage that the product purity is high and is suitable for industrial production. The method comprises the following steps: completely dissolving the crude product of caltrop total saponins in water; adding 1% acetum and mix; stirring and adding treated IRP64 resin; performing ion exchange at 25 DEG C and at the stirring speed of 300r / min; standing, carrying out suction filtering and discarding the filtrate; eluting the filter cakes by 85% alcohol; then, filtering; combining the eluant and the filtrate, and decompressing and recovering alcohol; and drying the raffinate to obtain a refined product of caltrop total saponins. The content of caltrop total saponins is over 90%.

Description

technical field [0001] The invention relates to the field of refining industrial products, in particular to a process for purifying total saponins of Tribulus terrestris. Background technique [0002] Tribulus terrestris (FUCTUS TRIBULI) is the dry and mature fruit of Tribulus terrestris L., a plant of the family Tribulus. It has the effects of calming the liver and relieving depression, promoting blood circulation and expelling wind. Commonly used traditional Chinese medicines recorded in Pharmacopoeia. The medicinal material contains various effective chemical components such as tribulus saponins, flavonoids, alkaloids and polysaccharides. Pharmacological research results show that total saponins of Tribulus terrestris have protective effects on cardiovascular and cerebrovascular, and can inhibit the growth of tumor cells in vitro. It has been reported in the literature that the effect of separating and purifying total saponins from Tribulus terrestris with macroporous a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28
Inventor 吴娟
Owner SUZHOU GULI BIOTECH