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Oprf/i agents and their use in hospitalized and other patients

A technology for patients and victims, applied in the field of monoclonal or polyclonal antibodies or their pharmaceutical compositions

Inactive Publication Date: 2013-08-28
VALNEVA AUSTRIA GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After 1991, there have been no follow-up studies using PV vaccines

Method used

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  • Oprf/i agents and their use in hospitalized and other patients
  • Oprf/i agents and their use in hospitalized and other patients
  • Oprf/i agents and their use in hospitalized and other patients

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Embodiment Construction

[0048] definition:

[0049] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0050] As used herein, the term "antibody" includes whole antibodies and any antigen-binding fragment (ie, "antigen-binding portion") or single chains thereof. Naturally occurring "antibodies" are glycoproteins comprising at least two heavy (H) chains and two light (L) chains inter-connected by disulfide bonds. Each heavy chain is comprised of a heavy chain variable region (abbreviated herein as VH) and a heavy chain constant region. The heavy chain constant region consists of three domains, CH1, CH2 and CH3. Each light chain is comprised of a light chain variable region (abbreviated herein as VL) and a light chain constant region. The light chain constant region includes one domain, CL. The VH and VL regions can be further subdivided into regions of hyperva...

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Abstract

The present invention relates to a new use of a vaccine comprising a fusion protein that comprises the Pseudomonas aeruginosa outer membrane protein I (OprI or OMPI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the Pseudomonas aeruginosa outer membrane protein F (OprF or OMPF), as well as to a new use of a monoclonal or polyclonal antibody against this fusion protein or a pharmaceutical composition thereof.

Description

technical field [0001] The present invention relates to novel uses of vaccines comprising a fusion protein comprising a protein fused to the outside of Pseudomonas aeruginosa through its amino terminal Pseudomonas aeruginosa outer membrane protein I (also referred to herein as "OprI" or "OMPI") carboxy-terminal to the carboxy-terminal portion of membrane protein F (also referred to herein as "OprF" or "OMPF"). Background of the invention [0002] Nosocomial infection is an infection caused by treatment in a hospital or medical service unit. Infections were considered nosocomial if they first appeared 48 hours or more after admission or within 30 days of discharge. This type of infection is also known as a hospital-acquired infection (or healthcare-associated infection in general). In the United States, the Centers for Disease Control and Prevention estimates that approximately 1.7 million hospital-associated infections from all types of microorganisms, including bacteria, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/21C07K19/00C07K16/12A61K39/104A61K39/40
CPCA61K39/104A61P31/04C07K14/21A61K39/40C07K16/12C07K19/00
Inventor 克里斯托弗·克莱德罗伯特·施勒格尔克尔斯汀·韦斯特理施尼格
Owner VALNEVA AUSTRIA GMBH