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Paeonia plant extract and preparation method and applications thereof

A technology of extract and Paeonia spp. is applied in the pharmaceutical field of plant extracts, and can solve the problems of simplicity and no process.

Inactive Publication Date: 2013-09-04
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At the same time, so far, there is still no report on the extraction and preparation of Paeonia seed shells that are simple in process, low in cost and suitable for industrialization, and the clinical application of the extract in traditional Chinese medicine and natural medicine.

Method used

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  • Paeonia plant extract and preparation method and applications thereof
  • Paeonia plant extract and preparation method and applications thereof
  • Paeonia plant extract and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] "Example 1" preparation of the original medicinal powder of peony

[0028] The dried and mature seeds of peony (Paeonia suffruticosa) are taken, shelled by a sheller, and the obtained peony seed shells are pulverized by conventional methods, sieved, and made into peony seed shell fine powder with a particle size of 60-100 mesh to obtain the original peony medicinal powder.

Embodiment 2

[0029] "Example 2" preparation of Fengdan extract

[0030] Take the dried and mature seeds of Paeonia ostii, shell them with a sheller, and weigh 1000g of the obtained peony seed shells, crush them, and soak them in 10L of 70% ethanol for 24 hours, three times in total. The filtrates were combined three times, concentrated under reduced pressure until there was no alcohol smell, applied to the AB-8 macroporous adsorption resin, first eluted with water to remove impurities such as sugar, and then eluted with 80% ethanol, the eluate was concentrated in vacuo, spray-dried, That is, 100 g of tan powdery Paeonia plant extract was obtained, and the weight percent content of total polyphenols was 94% after testing, and the content of 6 kinds of stilbene components were respectively: suffruticosol A 9.88%, suffruticosol B 25.10%, suffruticosol C 2.22% %, trans-E-viniferin 10.03%, trans-suffruticosol D 9.27, gnetin H 32.91%.

Embodiment 3

[0031] "Example 3" Preparation of Peony Extract

[0032] Take the dried and mature seeds of peony (Paeonia lactiflora), shell them with a sheller, and weigh 1000g of the obtained peony seed shells, crush them, percolate with 24L of 95% ethanol, concentrate the percolation liquid under reduced pressure until it has no alcohol smell, On the D-101 macroporous adsorption resin, first eluted with water to remove impurities such as sugar, and then eluted with 95% ethanol, and the eluate was concentrated in vacuum and spray-dried to obtain 100g of tan powdery Paeonia genus extract , the weight percent content of total polyphenols is 96% after testing, and the contents of 6 kinds of stilbenes are: suffruticosol A 10.26%, suffruticosol B 35.54%, suffruticosol C 2.62%, trans-E-viniferin 5.03%, trans -suffruticosol D 7.46%, gnetin H 30.82%.

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Abstract

The invention provides a paeonia plant extract and a preparation method and applications thereof. The extract is prepared from paeonia seed cases, wherein the content of total polyphenol is 40%-90%, and the total polyphenol contains stilbene ingredient. Proved by experiment research, the extract or drug composition thereof can be used for preventing or treating fungus infection diseases, virus infection disease, cancer and other diseases.

Description

Technical field: [0001] The invention relates to a new pharmaceutical application of a plant extract, in particular to a Paeonia plant and the application of its extract in the preparation of drugs for treating or preventing fungal infection, viral infection and cancer, and belongs to the field of natural medicines. Background technique: [0002] Paeonia (Paeonia) is a shrub or herb of the Ranunculaceae (Ranunculacea) plant. There are about 35 species in the world, which are divided into 3 groups, namely the peony group, the North American Paeoniae group and the Paeoniae group, of which there are only two species in the Northeast Paeoniae group. In western North America; Paeoniae group is the largest group in the genus, which is herbaceous type, containing about 25 species, distributed in Eurasia, my country has 7 species, 2 subspecies; Peony group has 8 species, 3 subspecies, which are woody This type is endemic to my country. Most of the plants in this genus have bright flo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P31/12A61P31/10A61P35/00
Inventor 何春年肖培根彭勇肖伟
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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