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Preparation technology for increasing clarity of poplar flower injection

A preparation process, poplar flower technology, is applied in the field of preparation technology for improving the clarity of poplar flower injection, which can solve the problems of smoke-like substances, difficult to meet the clarity, unqualified tannin detection, etc., and achieve stable drug effect, convenient operation, and clear high degree of effect

Inactive Publication Date: 2013-09-11
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing Yangshuhua injection has the following problems that need to be solved: tannin, resin and other items are often unqualified, the clarity is difficult to meet the requirements of the "Chinese Veterinary Pharmacopoeia", and smoke-like substances will appear after long-term storage.

Method used

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  • Preparation technology for increasing clarity of poplar flower injection
  • Preparation technology for increasing clarity of poplar flower injection
  • Preparation technology for increasing clarity of poplar flower injection

Examples

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Effect test

Embodiment 1

[0026] A preparation process for improving the clarity of poplar injection, the specific steps are as follows:

[0027] Take the poplar flower medicinal material, add purified water to decoct twice, each time for 2 hours, add water 20 times and 15 times respectively, combine the decoction, filter, and concentrate under reduced pressure to contain 3g of crude drug per 1ml. Add ethanol to the concentrated solution to make the alcohol content 80%, refrigerate for more than 24 hours, filter, recover ethanol from the filtrate and concentrate under reduced pressure to about 6-8g of crude drug per 1ml, add ethanol to make the alcohol content 90%, refrigerate for 24 For more than an hour, filter with filter paper, adjust the pH value of the filtrate to 7.8-8.0 with 30% NaOH, and refrigerate for more than 24 hours. Filter the alcohol precipitation solution with filter paper, concentrate the filtrate under reduced pressure to no alcohol (6-8g of the original drug per 1ml), add water for...

Embodiment 2

[0029] A kind of preparation technology of salicurus injection comprises the steps:

[0030] Take the poplar flower medicinal material, add purified water to decoct twice, each time for 2 hours, combine the decoction liquid, filter, and concentrate under reduced pressure until each 1ml concentrated solution contains 3g of the original drug, and the concentrated solution is added with ethanol to make the alcohol content 80%. Refrigerate for more than 24 hours, filter, recover the ethanol from the filtrate and concentrate under reduced pressure to contain 6-8g of crude drug per 1ml, add ethanol to make the alcohol content to 90%, refrigerate for more than 24 hours, filter with filter paper, and obtain the alcohol filtrate;

[0031] Concentrate the alcohol filtrate under reduced pressure to no alcohol (each 1ml contains 6-8g of crude drug), dilute it with water for injection to contain 2g of crude drug per 1ml, refrigerate at 0-5°C for 48 hours to obtain water precipitation liqui...

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Abstract

The invention discloses a preparation technology for increasing the clarity of a poplar flower injection. The technology concretely comprises the following steps: extracting, concentrating, precipitating with alcohol, adjusting the obtained alcohol filtrate to be alkaline, recovering ethanol, precipitating after ethanol recovery, filtering the obtained water precipitation solution with filter paper, carrying out reduced pressure concentration of the obtained filtrate until each milliliter of the filtrate concentrate contains 5g of crude drugs, adjusting the pH value of the filtrate concentrate to 2.8-3.0 by using 20% HCl, refrigerating for 48h to obtain an acid precipitation solution, filtering the acid precipitation solution, adjusting the pH value of the obtained filtrate to 5.5-6.5 by using 20% NaOH, heating for boiling for 15min to obtain a boiling solution, adding active carbon and an antioxidant, adjusting the pH value of the obtained product, filtering through using a micro-porous filtering film, encapsulating, and disinfecting. In the invention, tannins in the poplar flower injection are removed through controlling the concentration of the traditional Chinese medicinal concentrate, adjusting the pH value, and combining with active carbon, so the problems of frequently unqualified tannins and resins, difficult according of the clarity with the Veterinary Pharmacopoeia of the People's Republic of China, and smoky substance appearing because long-term storage of common poplar flower injections are solved, thereby the qualified rate of the poplar flower injection is increased.

Description

technical field [0001] The invention relates to the technical field of poplar flower injection, in particular to a preparation process for improving the clarity of poplar flower injection. Background technique [0002] Yangshuhua injection is an injection prepared by extracting and purifying poplar medicinal materials. A large number of clinical trials have proved that it can clear away heat, detoxify and stop dysentery. It is clinically effective in treating piglet yellow and pullorum. The injection also faces many technical problems in the actual preparation process. The quality of the product prepared by the traditional injection preparation process has serious problems, including unqualified tannin detection and unqualified clarity. The most important problem is The removal of tannins in the preparation directly affects the quality and safety of the injection. [0003] Tannins, also known as tannins, are a complex class of polyphenolic compounds with large molecules and...

Claims

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Application Information

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IPC IPC(8): A61K36/76A61K9/08A61P31/04A61P1/12A61K133/00
Inventor 吴学渊房春林杨海涵李超李犹平
Owner CHENGDU QIANKUN VETERINARY PHARMA
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