Method for synthesizing 1-BOC-3-piperidone
A 1-BOC-3-, piperidinone technology, applied in the field of medicine, can solve problems such as being unsuitable for industrial production, a large amount of waste water, waste residue, complicated operation process, etc., and achieve the effects of mild conditions, short synthesis steps and good purity
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[0022] The following examples are used to further illustrate the present invention, but it should not be interpreted as that the scope of the above-mentioned themes of the present invention is limited to the following examples, and all technologies realized based on the above-mentioned content of the present invention all belong to the scope of the present invention.
[0023] 1. Synthesis of Step 1 compound 2 (3-hydroxypiperidine):
[0024] 1. Preparation of sodium borohydride solution: 113.5g of sodium borohydride, 150ml of water and 40ml of 20% NaOH aqueous solution were mixed.
[0025] 2. Synthesis: Put 95.1g of compound 1 (3-hydroxypyridine) into a 1L reaction flask, add 300ml of NaOH aqueous solution with a mass percentage of 20%, raise the temperature to 60°C, add sodium borohydride solution dropwise, keep warm for 1h, drop After the addition, the temperature was raised to 80°C and kept for 5 hours. After the heat preservation was completed, stirred and cooled to room te...
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