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Specially designed magnesium-aluminum alloys and medical uses thereof in hemodynamic environment

A magnesium alloy and blood vessel technology, applied in the field of open devices, can solve the problems of insufficient realization, unreflection, and insufficient time.

Active Publication Date: 2013-09-18
TRANSLUMINAL TECH LLC 930 ERIE BOULEVARD EAST SYRACUSE NEW YORK NY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, for the purposes of patent law, some or all of the patents / publications discussed may not be sufficiently old in time, may not reflect subject matter developed at a sufficiently early date and / or may not be sufficiently equivalent to existing technology

Method used

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  • Specially designed magnesium-aluminum alloys and medical uses thereof in hemodynamic environment
  • Specially designed magnesium-aluminum alloys and medical uses thereof in hemodynamic environment
  • Specially designed magnesium-aluminum alloys and medical uses thereof in hemodynamic environment

Examples

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Effect test

Embodiment 1

[0035] AZ31 implant material

[0036] This example describes the implantation of a base plate made of AZ31 into a sheep aorta in order to study the effect of this hemodynamic environment on the corrosion of this magnesium alloy.

[0037] image 3 (a)-(b) show pictures of 15-day-old sheep aortic (retroperitoneal route) explants versus non-eroded samples. image 3 (a) shows the bottom of the corresponding baseplate, and image 3 (b) shows the top of the corresponding baseplate, where the uncorroded baseplate sample is located at image 3 (a) and 3(b) on their respective left-hand sides. It is estimated that the time for complete absorption will be about 150 days.

[0038] The following examples are intended to characterize the effect of Al content on the alloy dissolution rate in a physiological hemodynamic environment. The biocompatibility of Mg is known, but a faster rate of bioabsorption is a goal of the closure device implant embodiment.

Embodiment 2

[0040] This example describes in vivo studies performed to determine bioabsorption kinetics by corrosion of certain Mg-Al alloys. This study was performed in vivo in the sheep femoral artery; the sheep femoral artery is a mimic of the human femoral artery model because it has similar blood flow conditions, similar blood chemistry, similar lumen and arterial wall physiology, and similar Endothelial Physiology. In addition, pathological tissue responses to implants are also similar to pathological tissue responses to implants in humans. Animals used in this study (animal G3924 - sacrificed at 8 hours; animal G3918 - sacrificed at 4 hours) were 2+ years old and 200+ lbs.

[0041] Briefly, a small cylindrical Mg alloy sample measuring 0.74 mm in diameter and 5.1 mm in length was implanted into the femoral artery of a sheep using an 18-gauge access needle (incision procedure), and the It is anchored to the blood vessel wall. In this manner, the sample is exposed to environmental...

Embodiment 3

[0064] Surface Pretreatment of Magnesium and Magnesium Alloys for Custom Corrosion Rates

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Abstract

The present invention relates generally to specially designed magnesium-aluminum ("Mg-Al") alloys and medical uses thereof in a hemodynamic environment, and, more particularly to devices for sealing an opening formed through biological tissue (such as blood vessels) made from such specially designed magnesium-aluminum alloys.

Description

[0001] Related application materials [0002] This application claims priority to US Provisional Patent Application No. 61 / 411698, filed November 9, 2010; the corresponding contents of all documents related to the aforementioned patents are hereby incorporated herein by reference. technical field [0003] The present invention relates generally to specially designed magnesium-aluminum ("Mg-Al") alloys and their medical use in the hemodynamic environment, and more particularly to A device used to seal openings made through biological tissue, such as blood vessels. Background technique [0004] Certain Mg alloys are known and have been used to form devices for sealing openings formed through biological tissue, such as blood vessels. See, for example, U.S. Patent Publication No. 20110046665, paragraphs [0015], [0018], [0025], and [0038] (describing a closure for sealing an opening formed through biological tissue). device comprising a base plate, a plug, and a wire, and wher...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06A61L27/04
CPCA61B2017/00831A61L27/047A61B17/0057A61L31/022
Inventor 斯蒂芬·格林R·罗布克海特
Owner TRANSLUMINAL TECH LLC 930 ERIE BOULEVARD EAST SYRACUSE NEW YORK NY