High-temporal-spatial-resolution nerve chip measuring device
A neural chip and measuring device technology, applied in electronic circuit testing and other directions, can solve problems such as the absence of nerve cell stimulation methods, and achieve the effects of diversified stimulation modes, short switching time, and high spatial and temporal resolution.
Inactive Publication Date: 2013-10-09
ZHEJIANG UNIV
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Problems solved by technology
At present, a high-throughput and high-spatial-resolution nerve cell stimulation method for this detection device has not yet appeared.
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[0035] figure 1 with figure 2 A structure of the neural chip is shown. The neural chip includes a microelectrode array and a cell growth chamber. The microelectrode array includes a substrate 1 on which microelectrodes are arranged; the cell growth chamber is fixed on the substrate 1. The cell growth chamber includes nine microgrooves and twelve microchannels. The nine microgrooves are arranged in an array of three rows and three columns on the substrate 1, and each microgroove and the microchannel are open. Two adjacent microgrooves are connected by a microchannel. For example, the first microgrooves 2 and the second microgrooves 3 are connected through the first microchannel 4, the second microgrooves 3 and the fourth microgrooves 5 are connected through the second microchannel 6, and the fourth microgrooves 5 and third The microgrooves 7 are connected through the third microchannel 8, and the third microgrooves 7 and the first microgrooves 2 are communicated through the f...
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Abstract
The invention discloses a high-temporal-spatial-resolution nerve chip measuring device. The nerve chip measuring device comprises an optical system which carries out photostimulation on nerve cells, and a circuit system. The circuit system is used for processing electric signals collected by micro electrodes of the nerve chip. Ultraviolet faculae generated by the optical system are distributed in an arrayed mode. The arrangement manner of the ultraviolet faculae is identical with the arrangement manner of the micro electrodes on the nerve chip. The ultraviolet faculae are correspondingly lighted on the micro electrodes of the nerve chip in a one-to-one mode. A specific cell or more specific cells of a nerve cell net on the nerve chip can be stimulated with the high-temporal-spatial-resolution nerve chip measuring device, and potentials outside the cells are recorded at the same time. In addition, according to the high-temporal-spatial-resolution nerve chip measuring device, multiple-site multiple-mode photostimulation capable of being accurately controlled can be performed on the nerve cell network which grows on the measuring device in an orientated mode.
Description
Technical field [0001] The invention relates to a device for stimulating nerve cells and detecting nerve cell electrical signals. Background technique [0002] The analysis of neural electrical signals is one of the main contents of current neuroinformatics research. The most commonly used device is the Micro-Electrode Array (MEA). MEA consists of microelectrodes embedded on a substrate. Microelectrodes are mainly composed of metal materials, such as platinum, gold, titanium nitride, and indium tin oxide. The microelectrodes are arranged in an array on the substrate material. The microelectrodes are connected to wires made of gold or transparent indium tin oxide, and the wires transmit the weak electrical signals collected by the microelectrodes to an external amplifier. [0003] As an emerging research field, neural chip technology is developed on the basis of microelectrode array technology. Neural chip technology uses micro-processing technology to process a group of micro-...
Claims
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Inventor 叶学松田健涂春龙王飞翔
Owner ZHEJIANG UNIV