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Application of Chukrasone B in preparing medicines for treating acute renal failure

A technology for acute renal failure and drugs, applied in the direction of drug combinations, pharmaceutical formulas, organic active ingredients, etc., to achieve the effect of strong inhibitory activity and prominent substantive characteristics

Active Publication Date: 2015-07-22
JIANGSU SHENLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few clinical drugs that have obvious effects on improving renal blood perfusion disorder and reducing renal tissue damage

Method used

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  • Application of Chukrasone B in preparing medicines for treating acute renal failure
  • Application of Chukrasone B in preparing medicines for treating acute renal failure
  • Application of Chukrasone B in preparing medicines for treating acute renal failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Chukrasone B tablet involved in the present invention:

[0013] Take 20 grams of compound Chukrasone B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of the compound Chukrasone B capsules involved in the present invention:

[0015] Get 20 grams of compound Chukrasone B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0018] Experimental Example 1 The therapeutic effect of Chukrasone B on rats with acute renal failure

[0019] (1) Experimental method

[0020] Rat animal model of acute renal failure induced by intramuscular injection of glycerol. 60 healthy male SD rats of 180-220g were selected and randomly divided into 5 groups: sham operation group (intramuscular injection of normal saline); model group (intramuscular injection of glycerol); Chukrasone B Ⅰ group (0.3 mg / Kg)); Chukrasone B Group Ⅱ (0.6 mg / Kg)); Chukrasone B group Ⅲ (1.2 mg / Kg)), the rats in each group were injected with normal saline or Chukrasone B into the tail vein immediately after glycerol modeling, and administered again after 12 and 24 hours .

[0021] (2) Observation indicators

[0022] After the last administration of Chukrasone B or normal saline, 60 rats were put into metabolic cages to collect urine for 24 hours. Six hours after the urine retention, they were anesthetized by intraperitoneal injection of 4% c...

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PUM

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Abstract

The invention relates to a novel medical use of Chukrasone B, and in particular relates to an application of Chukrasone B in preparing medicines for treating acute renal failure. The use of the Chukrasone B in preparing medicines for treating acute renal failure provided by the invention is disclosed for the first time. As the framework type belongs to a brand-new framework type, and the inhibiting activity of the Chukrasone B to acute renal failure is unimaginably strong, the probability of giving any enlightenment by other compounds does not exist. The Chukrasone B has remarkable substantial characteristics and meanwhile has remarkable progress for treating acute renal failure.

Description

technical field [0001] The present invention relates to the field of medicinal chemistry. Specifically, the present invention relates to a new medical application of Chukrasone B, that is, the application of Chukrasone B in the preparation of medicines for treating acute renal failure. Background technique [0002] Acute Renal Failure (ARF) is a clinical syndrome caused by a variety of reasons, which can be seen in patients from various clinical departments. It has a high incidence and often brings serious consequences. ) sharp decline in mental function, clinical manifestations of acute oliguria (urine output <400mLPd) or anuria (urine output <100mLPd), obstacles in the excretion of nitrogen metabolites in the body, rapid azotemia, water and electrolytes, acid-base Balance disorder, and cause the corresponding dysfunction of the system of the whole body. The main factors causing acute renal failure are the sharp reduction of renal blood flow, as well as the oxidativ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P13/12
Inventor 丁圣雨
Owner JIANGSU SHENLONG PHARMA