Preparation method of magnetic fluorescent composite nanospheres

A technology of nanospheres and fluorescence, which is applied in the field of preparation of magnetic fluorescent composite nanospheres, can solve the problems of not being able to achieve magnetic maneuverability and strong fluorescence properties at the same time, affecting the quantum yield of quantum dots, and low saturation magnetization of materials, etc., to achieve Easy to operate, consistent thickness, and uniform particle size

Inactive Publication Date: 2013-10-30
BEIJING UNIV OF CHEM TECH
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Problems solved by technology

However, due to the direct contact of quantum dots with ferric oxide, fluorescence bleaching occurs, which affects the quantum yield of quantum dots.
[0006] Z.G.Ju, Y.M.Lu, J.Y.Zhang, X.J.Wu, K.W.Liu, C.X.Shan, B.S.Li, D.X.Zhao, Z.Z.Zhang, B.H.Li, B.Yao, D.Z.Shen.Cryst.Growth Des., 2008, 8(8): 2733-2735 studied Fe 2+ The doped compounded Cd 1-x Fe x Se product optical effects, they found that Fe 2+ Doping is beneficial to the product to form a stable wurtzite structure, but the quality of all doped grains is far inferior to that of a single material grain, and its properties are not a simple superposition of the properties of two single crystals, and cannot Simultaneously achieve the purpose of magnetic maneuverability and strong fluorescence performance
[0007] B.Liu, D.Wang, W.Huang, M.J.Yu, A.Yao.Mater.Res.Bull., 2008, 43(11): 2904 2911 using SiO 2 Coated magnetic nanomaterial Fe 3 o 4 , and then use the silane coupling agent to modify the surface of the magnetic silicon spheres with amino functional groups, and finally the quantum dots CdSe are adsorbed to the surface under electrostatic action, and the magnetic fluorescent composite core-shell structure material is prepared, but the nanomaterial is coated with a very thick shell, resulting in a lower saturation magnetization for the material

Method used

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  • Preparation method of magnetic fluorescent composite nanospheres
  • Preparation method of magnetic fluorescent composite nanospheres
  • Preparation method of magnetic fluorescent composite nanospheres

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) Preparation of CdSe quantum dots

[0031] First is Na 2 SeSO 3 Preparation of precursor solution, 5mmolNa 2 SO 3 , 0.5mmol selenium powder and 100mL deionized water were added into a 250mL three-neck flask, and the pH was adjusted to 9 with 1mol / L NaOH aqueous solution. In rapid stirring and passing N 2 Under the conditions, the temperature was raised to 100°C. As the reaction time prolongs, the color of the solution gradually changes from gray-black to colorless, clear and transparent, indicating that the selenium powder has been completely dissolved.

[0032] Cd 2+ Preparation of precursor solution: Add 3 mL of deionized water, 1 mmol of cadmium acetate and 2.4 mmol of N-acetylcysteine ​​powder into a test tube, and dissolve them by ultrasonic waves.

[0033] Cd that will be made 2+ The precursor solution was quickly added to the pre-prepared Na 2 SeSO 3 In the precursor solution, under rapid mechanical stirring and N 2 Under the condition of 100°C, the...

Embodiment 2

[0041] (1) Preparation of CdSe quantum dots

[0042] First is Na 2 SeSO 3 Preparation of precursor solution, 5mmolNa 2 SO 3 , 0.5mmol selenium powder and 100mL deionized water were added into a 250mL three-neck flask, and the pH was adjusted to 9 with 1mol / L NaOH aqueous solution. In rapid stirring and passing N 2 Under the conditions, the temperature was raised to 100°C. As the reaction time prolongs, the color of the solution gradually changes from gray-black to colorless, clear and transparent, indicating that the selenium powder has been completely dissolved.

[0043] Cd 2+ Preparation of precursor solution: Add 3 mL of deionized water, 1 mmol of cadmium acetate and 2.4 mmol of N-acetylcysteine ​​powder into a test tube, and dissolve them by ultrasonic waves.

[0044] Cd that will be made 2+ The precursor solution was quickly added to the pre-prepared Na 2 SeSO 3 In the precursor solution, under rapid mechanical stirring and N 2 Under the condition of 100°C, the...

Embodiment 3

[0047] (1) Preparation of CdSe quantum dots

[0048] First is Na 2 SeSO 3 Preparation of precursor solution, 5mmolNa 2 SO 3 , 0.5mmol selenium powder and 100mL deionized water were added into a 250mL three-neck flask, and the pH was adjusted to 9 with 1mol / L NaOH aqueous solution. In rapid stirring and passing N 2 Under the conditions, the temperature was raised to 100°C. As the reaction time prolongs, the color of the solution gradually changes from gray-black to colorless, clear and transparent, indicating that the selenium powder has been completely dissolved.

[0049] Cd 2+ Preparation of precursor solution: Add 3 mL of deionized water, 1 mmol of cadmium acetate and 2.4 mmol of N-acetylcysteine ​​powder into a test tube, and dissolve them by ultrasonic waves.

[0050] Cd that will be made 2+ The precursor solution was quickly added to the pre-prepared Na 2 SeSO 3 In the precursor solution, under rapid mechanical stirring and N 2 Under the condition of 100°C, the...

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Abstract

The invention provides a preparation method of magnetic fluorescent composite nanospheres. The preparation method comprises the steps of (1) preparing CdSe quantum dots by taking Na2SO3, selenium powder, cadmium acetate, N-acetylcysteine and deionized water as raw materials; (2) with FeCl3.6H2O sodium acetate anhydrous and ethylene glycol as raw materials, reacting in an autoclave to obtain Fe3O4 nanoparticles; (3) preparing a Fe3O4@SiO2 product by taking the Fe3O4 nanoparticles, tetraethoxysilane, absolute ethyl alcohol, deionized water and ammonium hydroxide as raw materials; and (4) conducting amino modification on the surface of the Fe3O4@SiO2 by utilizing a silane coupling agent KH-550, then loading CdSe onto the surface of the SiO2 through reaction, so as to obtain the final product magnetic fluorescent composite nanospheres. The preparation method has the characteristics that the prepared CdSe quantum dots have excellent water solubility and excellent fluorescent property and are about 3-4nm in diameter; the Fe3O4 nanoparticles are even in particle size and have good dispersity; the Fe3O4@SiO2 nanoparticles have an obvious core-shell structure, shell layers are evenly coated and are consistent in thickness; the magnetic fluorescent composite nanospheres has strong magnetism and excellent fluorescence property and can be used for site-specific drug transportation in a biological body and the fluorescence imaging of the biological body.

Description

technical field [0001] The invention relates to a method for preparing a magnetic fluorescent composite nanosphere. The composite nanosphere has both the fluorescent performance of quantum dots and the magnetism of ferric oxide, and can be used in the aspects of directional transport of drugs in living organisms and biological fluorescence imaging. Background technique [0002] The fluorescence emission wavelength of quantum dots is related to the composition of the material and the particle size, and the fluorescence peak is narrow and symmetrical, and the fluorescence intensity is hardly affected by the surrounding environment (such as pH value, solvent, temperature, etc.). The wavelength range of the excitation spectrum of quantum dots is very wide, and all quantum dots can be excited by ordinary ultraviolet lamps, which brings great convenience to biological research. Due to its superparamagnetism, ferric iron tetroxide magnetic nanoparticles have a wide range of applica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02C09K11/88C09K11/02B82Y30/00B82Y40/00G01N21/64A61K47/02A61K47/04A61K49/00
Inventor 郭广生刘改顾福博王志华韩冬梅
Owner BEIJING UNIV OF CHEM TECH
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