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Application of maggot extract in preparing medicament that enhances immunity of inactivated vaccine for pigeon Newcastle disease

A technology of inactivated vaccines and grain worms, which can be used in drug combinations, medical raw materials derived from arthropods, allergic diseases, etc., can solve problems such as no patent application, improve immune effect, increase immunity, and reduce the use of Effect

Active Publication Date: 2013-11-13
江苏欧克动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether grain worms can enhance the antibody level of pigeons immune to Newcastle disease inactivated vaccine has not been reported, and no patent has been applied for

Method used

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  • Application of maggot extract in preparing medicament that enhances immunity of inactivated vaccine for pigeon Newcastle disease
  • Application of maggot extract in preparing medicament that enhances immunity of inactivated vaccine for pigeon Newcastle disease
  • Application of maggot extract in preparing medicament that enhances immunity of inactivated vaccine for pigeon Newcastle disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Preparation of grain worm extract.

[0015] The grain worm extract is obtained through the following methods:

[0016] (1) Preparation of grain worms: the fly species is Lucilia sericata of Callidiaceae, 1 kg of EM stock solution, 1.5-2.5 kg of brown sugar, 46 kg of water, 0.2% potassium dihydrogen phosphate (analytical pure) (accounting for 0.2% of the weight of water) ). Dissolve brown sugar completely in water first, then add EM solution, and finally add potassium dihydrogen phosphate. Put the prepared solution into a white plastic bucket. During the day, when the outdoor temperature is above 22°C and below 38°C and there is plenty of sunlight, it can be cultivated outdoors. At night, it can be placed in an incubator, and the cultivation temperature should be adjusted at 30°C. . After EM culture for 36 hours, judge whether the preparation is successful according to the color, smell, pH value, etc.

[0017] Fly breeding and laboratory, control indoor te...

Embodiment 2

[0023] Example 2: Effect of grain worm extract on serum antibody level of immunized pigeons.

[0024] In order to study the effect of grain worm crude extract on the serum antibody level of Newcastle disease inactivated vaccine immunized pigeons, 20 healthy white feather king pigeons aged 1-2 were randomly divided into 4 groups, 5 in each group, and they were the low-dose grain worm group respectively. , the grain worm medium dose group, the grain worm high dose group, and the control group were kept at room temperature for one week, and the daily eating, drinking, and daily activities of the pigeons were observed, and they were used for the test after being confirmed to be normal. The grain worm extract was prepared according to the method of Example 1. After one week of normal feeding, 20 pigeons were immunized with Newcastle disease inactivated vaccine, 0.5ml / bird was injected into the chest muscle, and 0.5ml / bird was boosted one week later. On the second day after the inj...

Embodiment 3

[0033] Example 3: The protective effect of the grain worm extract on meat pigeons immune to Newcastle disease inactivated vaccine challenge.

[0034] Pigeons challenged with virulent paramyxovirus type 1 were used to further evaluate the immune enhancement effect of grain worm extract on Newcastle disease inactivated vaccine. 150 1-year-old healthy white-feathered king pigeons were randomly divided into 5 groups, 30 in each group, which were the first group: the immune challenge group fed with grain worm extract; the second group: immune challenge without feeding the grain insect extract group; the third group: feeding the grain worm extract and not immune challenge group; the fourth group: not feeding the grain worm extract and not immune challenge group; the fifth group: not feeding the grain worm extract and not immune Poison group. Normal feeding at room temperature for one week, observe the daily eating, drinking, and daily activities of the pigeons, and use them for exp...

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PUM

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Abstract

The invention discloses an application of maggot extract in preparing medicament that enhances immunity of inactivated vaccine for pigeon Newcastle disease. According to the invention, live maggots are induced through supersonic wave, bodies are crashed to obtain extract as an additive to pigeon forge or drinking water, and immunization effect of pigeon Newcastle disease vaccine is improved, therefore immunity against pigeon pest is enhanced. Through the immunopotentiation of the maggot, protection rate of Newcastle disease vaccine is improved, use of antiviral drug is greatly reduce, which is beneficial for production of nuisance-free foodstuff and the effective rate is up to 100%.

Description

technical field [0001] The invention relates to the application of grain worm extracts in the preparation of medicines for enhancing the immunity of pigeon Newcastle disease vaccines, and belongs to the technical field of poultry medicines. Background technique [0002] Pigeon Newcastle disease inactivated vaccine can be used to prevent pigeons from paramyxovirus type 1 infection (commonly known as pigeon plague), the immune protection rate is 70%-85%, and the immune protection period is 8-10 months. Since there is no pigeon-specific inactivated vaccine in China Vaccine, so although this protective effect can protect most pigeons from the infection of paramyxovirus type 1, there are important shortcomings, that is, the antibody level drops rapidly, and the immune protection period is short. If the protection period can be extended, it can be guaranteed for one year 12 months can be protected. Seeking to enhance the immune effect of pigeon plague and prolonging the immune pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P37/04
Inventor 蒋加进戴鼎震张姝仇明生张淼武毅
Owner 江苏欧克动物药业有限公司
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