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Veterinary menbutone powder and preparation method thereof

The technology of montbutrone powder and montbutrone is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, powder transportation, etc. Simple process, advanced prescription, and the effect of improving the level of veterinary medicine

Active Publication Date: 2015-01-14
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in Europe and other regions, menbutone has been used in horses, cattle, sheep, goats, pigs and dogs for indigestion, loss of appetite, anorexia, postpartum fasting, moldy feed poisoning, colic, constipation, ketosis, Toxemia (including pregnancy toxemia), digestive dysfunction caused by liver and pancreatic diseases, etc., but there are few reports in our country, and there is no import or related patent information

Method used

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  • Veterinary menbutone powder and preparation method thereof
  • Veterinary menbutone powder and preparation method thereof
  • Veterinary menbutone powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1, the preparation technology research of veterinary monbutrone powder

[0013] Prescription: menbutone 300g, starch (or dry starch) 2700g.

[0014] Preparation process I (direct mixing process): Weigh monbubutone and starch according to the prescription amount, mix for 20 minutes, and pass through a No. 5 sieve to obtain the product.

[0015] Preparation process II (mixing process after pretreatment of excipients): dry the starch at 80±2°C for 4 hours to make the water content ≤6.0%, to obtain dry starch for later use; weigh menbutone and dry starch according to the prescription amount, and mix for 20 minutes , pass through a No. 5 sieve, and you get it.

[0016] Preparation process III (step-by-step mixing process after pretreatment of auxiliary materials): dry the starch at 80±2°C for 4 hours to make the water content ≤6.0%, to obtain dry starch for later use; weigh menbutone and dry starch according to the prescription amount, and Mengbutone is first mi...

Embodiment 2

[0023] Embodiment 2, the preparation of veterinary menbutanone powder (small test)

[0024] Prescription: Menbutone 300g, dry starch 2700g.

[0025] Preparation process: Weigh menbutone and dry starch according to the prescription amount, put menbutone into the internal horizontal trough-shaped single-pulp mixer at one time, add 1 / 3 of the prescription amount of dry starch, mix for 5 minutes, and then add 1 / 3 prescription amount of dry starch, mix for 5 minutes, then add 1 / 3 of the prescription amount of dry starch, mix for 20 minutes, put the mixture in a stainless steel universal grinder for 5 minutes, pass through a No. 5 sieve, and pack it in aluminum-plastic composite In a film packaging bag, 10g per bag, heat-sealed, ready to use.

[0026] According to the above-mentioned prescription and preparation process, three batches of veterinary menbuconone powder samples were prepared in a small test, and the results are shown in Table 2.

[0027] Table 2 Preparation of 3 bat...

Embodiment 3

[0035] Embodiment 3, the preparation of veterinary monbutronone powder (pilot test)

[0036] Prescription: menbutone 3kg, dry starch 27kg.

[0037] Preparation process: Weigh menbutone and dry starch according to the prescription amount, put menbutone into the internal horizontal trough-shaped single-pulp mixer at one time, add 1 / 3 of the prescription amount of dry starch, mix for 5 minutes, and then add 1 / 3 prescription amount of dry starch, mix for 5 minutes, then add 1 / 3 of the prescription amount of dry starch, mix for 20 minutes, put the mixture in a stainless steel universal grinder for 5 minutes, pass through a No. 5 sieve, and pack it in aluminum-plastic composite In a film packaging bag, 10g per bag, heat-sealed, ready to use.

[0038] According to the above prescription and preparation process, 3 batches of veterinary menbuconone powder samples were prepared in pilot scale, and the results are shown in Table 4.

[0039] Table 4 Preparation of 3 batches of veterina...

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Abstract

The invention discloses a veterinary menbutone powder. The veterinary menbutone powder comprises menbutone and dry starch at mass ratio of 1:9, and the moisture content of the dry starch is no less than 6.0%. A preparation method of the venterinary membutone powder comprises the following steps of: by taking one part by weight of menbutone, firstly adding 3 parts by weight of dry starch, mixing for 5 to 10 minutes, then adding 3 parts by weight of dry starch, mixing for 5 to 10 minutes, finally adding 3 parts by weight of dry starch, mixing for at least 15 minutes, crushing the mixture, sieving with a NO.5 sieve, thus obtaining the veterinary menbutone powder. The veterinary menbutone powder is prepared by adopting a step-by-step mixing and crushing technology, the preparation method is simple and convenient to operate, stable in technology, and good in repeatability, all indexes of character, appearance uniformity, granularity, mobility, repose angle and the like of the obtained veterinary menbutone powder can meet the regulations on the related powder in Chinese Veterinary Pharmacopiea (2010 edition), and the veterinary menbutone powder can be used for filling a blank of the veterinary cholagogue in China, and is beneficial to improvement of the veterinary medicine level of China.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a veterinary pharmaceutical preparation and a preparation method thereof. Background technique [0002] Animal husbandry is an important industry in my country's national economy and an important part of agriculture. Literature shows that in veterinary clinics, digestive system diseases of pigs, sheep, cattle and other animals account for about 30% of the total clinical incidence, while gastrointestinal dysfunction such as loss of appetite, indigestion, constipation, abdominal distension, gastrointestinal relaxation, and rumen accumulation , concomitant or secondary to almost all diseases in animals. Animal indigestion can hinder the growth and development of animals, reduce production performance or even die, often causing large economic losses and hindering the development of animal husbandry. At present, for such diseases, cholinergic drugs such as bethanec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/192A61K47/36A61P1/16
Inventor 罗永煌罗雷龙飞王帅王兰周杨游吴梦婉谭明国
Owner SOUTHWEST UNIV
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