Menbutone injection liquid for veterinary use and preparation method thereof

Abstract

The invention discloses menbutone injection liquid for veterinary use. Every 100 ml of the menbutone injection liquid is prepared from: 10g of menbutone, 5.5g of diethanol amine, 0.2g of chlorocresol, 0.2g of sodium metabisulfite or sodium sulfite, 0.2g of edetic acid, and the balance of water for injection. The preparation method includes the steps of taking 45-55 ml of the water for injection, adding the diethanol amine into the water for injection to stir and mix evenly, adding the menbutone to stir until the mixture is fully dissolved at 50+ / -5 DEG C, then adding the sodium metabisulfite or the sodium sulfite and the edetic acid, stirring the mixture to make the mixture dissolve, then adding the chlorocresol, stirring the mixture and making the mixture dissolve at 50+ / -5 DEG C, cooling the mixture to indoor temperature, using the water for injection to carry out constant volume to 100 ml, mixing the mixture evenly, filtering the mixture through a millipore filter with a 0.45 micron pore diameter and a millipore filter with a 0.22 micron pore diameter in sequence, carrying out nitrogen charge, encapsulation and sterilization, and then obtaining the menbutone injection liquid for veterinary use. The prescription of the injection liquid is advanced, simple in process, good in repeatability, stable and effective in product quality, and the injection liquid prepared through the method is proper in PH value, and can be dosed through intramuscular injection or vein injection, fills the blank of cholagogue for veterinary use in China, and contributes to improve the level of drug use by veterinarians in China.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a veterinary pharmaceutical preparation and a preparation method thereof. Background technique [0002] Animal husbandry is an important industry in my country's national economy and an important part of agriculture. Literature shows that in veterinary clinics, digestive system diseases of pigs, sheep, cattle and other animals account for about 30% of the total clinical incidence, while gastrointestinal dysfunction such as loss of appetite, indigestion, constipation, abdominal distension, gastrointestinal relaxation, and rumen accumulation , concomitant or secondary to almost all diseases in animals. Animal indigestion can hinder the growth and development of animals, reduce production performance or even die, often causing large economic losses and hindering the development of animal husbandry. At present, for such diseases, cholinergic drugs such as bethanec...

AI Technical Summary

Problems solved by technology

At present, in Europe and other regions, menbutone has been used in horses, cattle, sheep, goats, pigs and dogs for indigestion, loss of appetite, anorexia, postpartum fasting, moldy feed poisoning, colic, constipation, ketosis, Toxemia (including pregnancy toxemia), digestive dysfunction caused by liver and pancreatic diseases, etc., but there are few reports in our country, and there is no import or related patent information

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