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A kind of preparation technology of ointment tube for anorectal administration

A preparation process and drug administration technology, which is applied in the field of preparation of anorectal drug ointment tubes, can solve problems such as the smoothness of the burr drug outlet, the neck of the tube is not soft enough, and complicated and numerous processes, and achieves process saving, good hand feeling, and easy to use. The effect of industrialization

Active Publication Date: 2016-01-20
西安宏瑞药用包装科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process is complex and complicated, the production cost is high, and the neck of the produced product is not soft enough, causing discomfort to the human body during use
On the other hand, the ointment tube product prepared by ordinary blow molding process will produce burrs on the outer wall of the catheter end and the smoothness of the drug outlet can not meet the requirements

Method used

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  • A kind of preparation technology of ointment tube for anorectal administration
  • A kind of preparation technology of ointment tube for anorectal administration
  • A kind of preparation technology of ointment tube for anorectal administration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] combine figure 1 and figure 2 , Heat and knead polyethylene and 5% polyethylene mass masterbatch in the barrel of the extruder at a heating temperature of 120°C, extrude the obtained molten material into a straight tubular parison through a die, and set a Blow molding mold 4, when the straight tubular parison in the blow molding mold 4 reaches the required length, close the mold; feed compressed gas 5 for blow molding, the required pressure of compressed gas 5 is 0.6MPa, and the feeding time is 4s , to obtain the molded pipe body 6; when blow molding, inject cooling water with a temperature of -35°C into the cooling channel of the blow mold 4, and the flow rate of the cooling water is 10m 3 / h, cooling and shaping the formed pipe body 6; image 3 , the cooled forming tube body 6 is placed in the clamping mold 7, and the upper and lower ends of the forming tube body 6 are cut off, so as to respectively realize the water-cutting port of the drug delivery catheter 2 and...

Embodiment 2

[0027] Heat and knead the color masterbatch with 4% mass of polypropylene and polyethylene in the barrel of the extruder at a heating temperature of 170°C, and extrude the obtained molten material into a straight tubular parison through a die. Plastic mold, when the straight tubular parison in the blow mold reaches the required length, close the mold; feed compressed gas for blow molding, the pressure of the required compressed gas is 0.5MPa, and the time for feeding is 2s to obtain a molded pipe body ; When blow molding, inject cooling water with a temperature of -30°C into the cooling water channel of the blow molding mold, and the flow rate of the cooling water is 10m 3 / h, cooling and shaping the formed tube body; putting the cooled formed tube body into the clamping mold, cutting off the upper and lower ends of the formed tube body, so as to respectively realize the water cutting port of the drug delivery catheter 2 and the tube Cut the tail of the body tail; then put the...

Embodiment 3

[0029] Heat and knead polyvinyl chloride and 6% polyvinyl chloride color masterbatch in the barrel of the extruder at a heating temperature of 150°C, and extrude the obtained molten material into a straight tubular parison through the die head. There is a blow molding mold, when the straight tubular parison in the blow molding mold reaches the required length, the mold is closed; the compressed gas is fed into the blow molding, the required pressure of the compressed gas is 0.5MPa, and the feeding time is 3s, and the molding is obtained Pipe body; inject cooling water with a temperature of -28°C into the cooling water channel of the blow mold, and the flow rate of the cooling water is 11m 3 / h, cooling and shaping the formed tube body; putting the cooled formed tube body into the clamping mold, cutting off the upper and lower ends of the formed tube body, so as to respectively realize the water cutting port of the drug delivery catheter 2 and the tube Cut the tail at the tail ...

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Abstract

The invention discloses a preparation process of an anorectal administration ointment tube. The preparation process comprises the following steps of mixing thermoplastic plastics in the charging barrel of an extruder by heating, extruding the molten material obtained into a straight tube parison through a die head, arranging a blowing mould under the die head, and closing the mould when the straight tube parison in the blowing mould is long enough as required; introducing a compressed gas for blow moulding to obtain a moulded tube body composed of a tube body and an administration conduit; cooling and setting; next, putting the tube body into a clamping mould, and cutting out the upper and lower end portions of the moulded tube body to correspondingly realize the degating of the administration conduit and the tail shearing of the tail part of the tube body, respectively; furthermore, putting the moulded tube body into a high temperature zone in a range from 400 to 500 DEG C, and blowing high-temperature hot air to the moulded tube body from top to bottom so that burrs are molten and shrank; punching the administration conduit of the moulded tube body by using a puncher pin so that the end portion of the administration conduit is formed into a composite structure which is smoothly crimped inwards, thus obtaining the anorectal administration ointment tube. The preparation process is simple and stable, low in need for equipment, and applicable to industrialization.

Description

technical field [0001] The invention belongs to the field of medical device preparation, and in particular relates to a preparation process of an anorectal drug ointment tube. Background technique [0002] The anorectal drug ointment tube is not only a container for storing medicines, but also a device used for drug treatment for patients. Because the catheter part needs to be inserted into the human body and contact the mucous membrane of the human body, in addition to the basic performance of the packaging container, this type of container must also be considered. It is a humanized problem of the shooting range and medication protection required by the drug delivery device. [0003] At present, the anorectal drug ointment tubes are often manufactured in separate parts. Generally, high-density polyethylene is used, which is first extruded and blown into a straight tube. Planar printing and spraying marks on the outer wall of the pipe body; then the pipe is set on the mandr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C49/04B29C49/42
Inventor 唐丽娟
Owner 西安宏瑞药用包装科技有限公司