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Application of Lycojaponicumin A in anti-tubercle bacillus drug

A technology for anti-tuberculosis and drugs, applied in the application field of preparing anti-tuberculosis drugs, to achieve the effects of strong tuberculosis inhibitory activity, expanded types, and broad application prospects

Active Publication Date: 2013-12-18
FENGJIE DONGYANG BUILDING MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of Lycojaponicumin A in anti-tubercle bacillus drug
  • Application of Lycojaponicumin A in anti-tubercle bacillus drug
  • Application of Lycojaponicumin A in anti-tubercle bacillus drug

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of the compound Lycojaponicumin A tablet involved in the present invention:

[0017] Take 20 grams of compound Lycojaponicumin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0018] Embodiment 2: the preparation of the compound Lycojaponicumin A capsules involved in the present invention:

[0019] Get 20 grams of compound Lycojaponicumin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental Example 1 Determination of Absolute Concentration of Lycojaponicumin A Anti-BCG (BCG) by Solid Medium Dilution Method

[0022] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1 ) turbidity, that is, to prepare 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0023] Make Lycojaponicumin A into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Lycojaponicumin A to 4ml Middlebrook7H11 agar medium according to the required dose (The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly to make Lycojaponicumin A, the concentrations are 6.0ug / ml, 4.0ug / ml, 3.0u...

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Abstract

The invention discloses application of Lycojaponicumin A in preparation of an anti-tubercle bacillus drug. Aiming at the situation that at present, the tuberculosis morbidity is high, multi-drug-resistant strains of mycobacterium tuberculosis are present and accordingly the tuberculosis morbidity and mortality are on the rise, we find that the Lycojaponicumin A has remarkable tubercle bacillus inhabiting activity and good application prospect. The application of the Lycojaponicumin A in the preparation of the anti-tubercle bacillus drug is disclosed for the first time. Due to the fact that the skeleton type is a novel skeleton type and the high tubercle bacillus inhabiting activity of the Lycojaponicumin A is previously unimagined, the possibility that other compounds give any revelation does not exist, and the Lycojaponicumin A has outstanding substantive characteristics and meanwhile has a remarkable improvement in prevention and curing of tubercle bacillus infection obviously.

Description

technical field [0001] The invention relates to the application field of pharmaceutical compounds, in particular to the application of Lycojaponicumin A in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/424A61P31/06
Inventor 江春平王慧
Owner FENGJIE DONGYANG BUILDING MATERIALS CO LTD
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