Biosensor and manufacturing method thereof

A biosensor and insulating layer technology, applied in biological testing, instruments, scientific instruments, etc., can solve technically difficult problems, achieve smooth and uniform diffusion, simple manufacturing methods, and improve accuracy

Active Publication Date: 2013-12-18
LEADWAY HK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the technical difficulty of improving the accuracy of biosensors to detect the concentration of glucose in human blood is very high.

Method used

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  • Biosensor and manufacturing method thereof
  • Biosensor and manufacturing method thereof
  • Biosensor and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Example 1 Using an elliptical reagent diffusion control zone to add reactive reagents to electrodes

[0095] like image 3 The shown biosensor includes an insulating base plate 1 , a working electrode 2 , a counter electrode 3 and a reference electrode 4 . The electrode system is covered with a reactive reagent diffusion control layer 5, the control layer 5 includes a reactive reagent diffusion control area 6 with an oval shape, and the opening area of ​​the reagent diffusion control area 6 is the same as the area of ​​the reagent to be added to the electrode and Just above the electrode active area. The biosensor described in this embodiment also includes a space fabrication layer 7 and an upper cover 8 with a vent hole.

[0096] In the biosensor fabrication process, the reaction reagent is added to the electrode through the elliptical reagent diffusion control area by the method of spotting. After the reagents were added to the electrode system, the distribution of...

Embodiment 2

[0098] Example 2 Using a circular reagent diffusion control zone to add reactive reagents to electrodes

[0099] like Figure 5 Shown is the reaction reagent diffusion control layer 5 in which the shape of the reaction reagent diffusion control region 6 is circular. In the biosensor fabrication process, the reaction reagent is added to the electrode through the circular reagent diffusion control area by the method of spotting. After the reagents were added to the electrode system, the distribution of the reagents on the electrodes was photographed with a digital stereo microscope (microscope model MOTICAM 2306, manufacturer McDior Industrial Group Co., Ltd.) to observe the distribution of the reagents on the electrodes. picture. like Image 6 It is shown that the added reaction reagent diffuses uniformly on the working electrode 2, the counter electrode 3 and the reference electrode, and no reagent overflows the edge 6-1 defined by the reagent diffusion control zone. And t...

Embodiment 3

[0101] Example 3 Addition of Reagents on Electrode System with Assisted Diffusion Electrode

[0102] like Figure 7 The electrode system of the shown biosensor includes functional electrodes 2 , 3 , 4 and an auxiliary electrode 12 . The biosensor also includes a reactive reagent diffusion control layer 5 with an oval shape 6 . In the biosensor fabrication process, the reaction reagent is added to the electrode through the elliptical reagent diffusion control area by the method of spotting. After the reagents were added to the electrode system, the distribution of the reagents on the electrodes was photographed with a digital stereo microscope (microscope model MOTICAM 2306, manufacturer McDior Industrial Group Co., Ltd.) to observe the distribution of the reagents on the electrodes. picture. like Figure 8 It is shown that the added reaction reagent diffuses uniformly on the electrode, and no reagent overflows the edge 6-1 defined by the reagent diffusion control zone. An...

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Abstract

The invention provides a biosensor and a method for manufacturing the biosensor. The biosensor comprises an insulating base plate, an electrode system, a reaction reagent and an insulating layer, wherein the insulating layer covers partial electrode system, and is formed with a closed region free from the insulating layer on the position of the reaction reagent; a closed boundary having no sharp angle is formed in the closed region enclosed by the insulating layer; the reaction reagent covers the closed region, and fails to exceed the closed boundary. Furthermore, the biosensor comprises an auxiliary diffusion electrode. The biosensor, through the closed boundary free from the sharp angle and the auxiliary diffusion electrode, can reduce an edge effect of the reagent, effectively distribute the reagent in a corresponding region of the electrode, effectively control the dosage of the reaction reagent, and reduce product cost. And the manufacturing method is simple.

Description

technical field [0001] The present invention relates to a biosensor for detecting the content of physiological indexes and a manufacturing method thereof. [0002] Background technique [0003] The field of healthcare testing has changed dramatically in recent years, from the initial use of clinical laboratory samples to the rapid testing that can be achieved simply in the doctor's office or at the patient's side. Disposable biosensors with electrode systems are often used for rapid detection. Taking the daily glucose detection of diabetic patients as an example, now patients only need to use disposable biosensors for detection at home to obtain the glucose level of the tested patient at that time, helping patients to understand their physical condition in time and adjust their diet accordingly. structure, or go to the hospital to let the doctor adjust the dosage according to the data of daily monitoring. Therefore, the accuracy of such disposable biosensors is particular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/327
CPCG01N33/5438G01N27/3272G01N27/4166G01N33/66
Inventor 章子毅葛浣溪
Owner LEADWAY HK
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