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Application of lycojaponicumin A in preparation of medicine for treating lung cancer

A drug and lung cancer technology, applied in the field of anti-tumor drugs, can solve the problem of damage to normal tissues and cells, and achieve the effect of strong cytotoxicity and prominent substantive characteristics

Active Publication Date: 2015-12-02
安徽创意达技术转移服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application.

Method used

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  • Application of lycojaponicumin A in preparation of medicine for treating lung cancer
  • Application of lycojaponicumin A in preparation of medicine for treating lung cancer
  • Application of lycojaponicumin A in preparation of medicine for treating lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound LycojaponicuminA tablet involved in the present invention:

[0013] Take 20 grams of compound Lycojaponicumin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0014] Embodiment 2: the preparation of compound LycojaponicuminA capsules involved in the present invention:

[0015] Get 20 grams of compound Lycojaponicumin A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: LycojaponicuminA inhibits the proliferation of lung cancer cells cultured in vitro and its effect on normal human cells

[0018] Take the lung cancer cells in the logarithmic growth phase (non-small cell lung cancer cell A 549 , large cell lung cancer cells NCI-H460, lung squamous cell carcinoma cells HTB-8, human lung squamous cell carcinoma cells QG-5) and human normal liver cells L02 were inoculated on 96-well culture plates, and the seeding volume per well was 3000-4000 cells / 100uL and 6000 cells / 100uL; aseptically collect 15mL of venous blood from healthy blood donors, anticoagulate with heparin, separate mononuclear cells by Ficoll density gradient centrifugation, prepare single cell suspension with RPMI1640 containing 10% fetal bovine serum, adjust Cell concentration was 2 x 10 5 cells / mL, inoculated in 96-well culture plate, 100uL per well. After 24 hours of cell culture on the above-mentioned culture plates, LycojaponicuminA 100uL of dif...

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Abstract

The invention discloses application of Lycojaponicumin A in preparation of medicaments for treating lung cancer. The compound shows good anti-lung cancer activity, can be used for preparing anti-lung cancer medicaments, and belongs to the technical field of new application of medicaments. The Lycojaponicumin A can prominently inhibit non-small cell lung cancer cells A549, large cell lung cancer cells NCI-H460, lung squamous cancer cells HTB-8 and human lung flat epithelial cancer cells QG-5 cultured in vitro, has a low inhibiting effect on human normal liver cells LO2 and peripheral blood lymphocytes, and shows obvious selectivity. The application of the Lycojaponicumin A in preparation of the medicaments for treating the lung cancer is made public for the first time; and because the skeleton type is completely novel, the Lycojaponicumin A has an unexpectedly strong lung cancer cell inhibiting activity.

Description

technical field [0001] The invention relates to the field of antitumor drugs, in particular to the application of LycojaponicuminA in the preparation of antitumor drugs. Background technique [0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application. It has become the direction and urgent task of current anticancer drug research to find highly efficient and low toxic drugs for treating tumors. Finding high-efficiency, low-toxic anticancer drugs has been considered an effective way. [0003] The present invention has confirmed by experiment that LycojaponicuminA has the effect on non-small cell lung cancer cell A cultured in vitro. 549 , large cell lung cancer cell line NCI-H460, lung squamous cell carcinoma cell line HTB-8 and human lung squamous epithelial cell line QG-5 have significant inhibi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/424A61P35/00A61P11/00
Inventor 张红丽
Owner 安徽创意达技术转移服务有限公司
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