RNAscop (TM) HPV assay for determining HPV status in head and neck cancers and cervical lesions

A head and neck cancer, HPV-16 technology, applied in biochemical equipment and methods, microbial determination/inspection, etc., can solve problems such as unpredictable effects, difficult assay methods, unclear high-specificity properties, etc.
CN103476948AInactive Publication Date: 2013-12-25ADVANCED CELL DIAGNOSTICS INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ADVANCED CELL DIAGNOSTICS INC
Publication Date
2013-12-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a method and a kit for determining whether a head and neck cancer is HPV-related. In one embodiment, an RNAscope (TM) HPV assay was designed to detect the presence of E6 / E7 mRNA of certain high-risk HPV subtypes related to head and neck cancer. The present invention also provides a method and a kit for determining whether a cervical lesion is a benign lesion or a cervical intraepithethial neoplasm lesion. In one embodiment, an RNAscope (TM) HPV assay was designed to detect the presence of E6 / E7 mRNA of certain high-risk HPV subtypes related to cervical cancer. The present invention further provides a method for determining the progression of cervical intraepithethial neoplasm based on the spatial pattern and levels of the E6 / E7 mRNA of certain high-risk HPV subtypes. The present invention also provides a method for determining the risk of developing cervical cancer in a human diagnosed with cervical intraepithethial neoplasm based on presence and absence of the certain subgroups of high-risk HPV subtypes.
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Description

[0001] Cross References to Related Applications

[0002] This application requires a filing date of January 28, 2011, and the title of the invention is "RNAscope for Determination of HPV Status in Head and Neck Cancer" TM Priority and benefit to U.S. Provisional Application No. 61 / 437,337 for HPV".

[0003] The entire content and disclosure of the aforementioned applications are incorporated by reference into this application. field of invention

[0004] Provided herein are methods and kits for determining whether head and neck cancer is associated with human papillomavirus (HPV) based on the presence or absence of E6 / E7 mRNA of high-risk HPV subtypes. This article also provides a method and a kit for diagnosing whether a subject's cervical lesions are benign according to the presence or absence of E6 / E7 mRNA of high-risk HPV subtypes. Also provided herein are methods for determining the progression of cervical intraepithelial neoplasia (CIN) based on the spatial pattern an...

Claims

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