Drug composition for treating cervical cancer and preparation method thereof

Abstract

The invention discloses a drug composition for treating the cervical cancer and a preparation method thereof. The drug composition comprises the following raw drugs: honeysuckle, zedoary, forsythia, chilopod, sinkiang arnebia root and amur corktree bark. The preparation method is characterized by firstly extracting the zedoary and the forsythia to obtain volatile oil, preparing the rest raw drugsinto powder and mixing the powder with the volatile oil to further process clinically acceptable external preparations including but not limited to suppository, effervescing agents, sprays, aerosol or paste. Pharmacodynamic experiments show the drug composition has remarkable anti-inflammatory effect and boosts cell apoptosis by differentiation-transformation, thus having effect on the SiHa cell of human cervical squamous cell carcinoma. The drug composition can directly inhibit growth of the cervical cancer cells, can achieve the aim of inhibiting tumors by regulating the molecular mechanismof P53 gene expression and is a safe, effective and side-effect-free external traditional Chinese drug preparation for preventing cervical lesions.

Description

field of invention [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for preventing and treating cervical cancer and a preparation method thereof. Background technique [0002] Cervical cancer is the second most common cancer in women, and even ranks first in some developing countries; there are about 500,000 new cases of cervical cancer in the world every year, and more than 200,000 people die from cervical cancer, of which 80% of the deaths occur in developing countries. There are 131,500 new cases of cervical cancer in my country every year, accounting for 28.8% of the total number of new cases of cervical cancer in the world. With the development of molecular biology and epidemiology, the research on the relationship between human papillomavirus (human papillomauirus, HPV) infection and lower reproductive tract diseases continues to deepen. It has been confirmed that the relation...

AI Technical Summary

Problems solved by technology

[0003] At present, it is considered that radiotherapy and surgery are effective methods for the treatment of cervical cancer. However, in many clinical cases with high risk factors, such as advanced cancer, barrel carcinoma, lymph node metastasis or small cell carcinoma, no matter whether surgery or radiotherapy is satisfactory, local recurrence of cervical tumors and Distant metastasis is the main cause of treatment failure. Even with modern radiotherapy equipment and radical surgery, it is difficult to cure. Moreover, the trauma is large and the side effects are severe. It may deprive young patients of their reproductive function and bring physical and mental pain. and the impact on the patient's quality of life are often unacceptable or intolerable to many women

For this reason, scholars have been committed to seeking new minimally invasive, less side effects, and limited effect methods that can cure tumors. With the continuous advent of new chemotherapy drugs and the continuous development of chemotherapy techniques, chemotherapy plays an increasingly important role in the treatment of cervical cancer. Important, but most anti-tumor drugs in modern medicine lack the effect of selectively inhibiting tumors. While killing tumor cells, they are often accompanied by varying degrees of toxic reactions

Images