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Preparation method and application of bezoar antidote tablet

A Niuhuang Jiedu Tablet and the technology of Niuhuang, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of large dosage for patients, rough process, and influence on clinical application, and achieve the effect of reducing dosage

Inactive Publication Date: 2014-01-08
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Niuhuang Jiedu Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients, which is inconvenient to take and serious. Affected the clinical application of this product

Method used

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  • Preparation method and application of bezoar antidote tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 5g of bezoar, 50g of realgar, 200g of gypsum, 200g of rhubarb, 150g of baicalin, 100g of platycodon, 25g of borneol, and 50g of licorice and add them to the CO2 supercritical extractor. Ethanol is used as an entrainer. The volume percentage of the entrainer in the total extraction solvent is 4%. , extraction pressure 15MPa, temperature 30°C, CO2 flow rate 1m1 / g crude drug min, extraction time 150min, supercritical extract was obtained, added starch, 70% ethanol to make granules, dried, pressed into tablets, made into 500 pieces, each piece weighed 0.5g.

Embodiment 2

[0018] Take 5g of bezoar, 50g of realgar, 200g of gypsum, 200g of rhubarb, 150g of scutellaria baicalensis, 100g of bellflower, 25g of borneol, and 50g of licorice into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take 5g of bezoar, 50g of realgar, 200g of gypsum, 200g of rhubarb, 150g of scutellaria baicalensis, 100g of bellflower, 25g of borneol, and 50g of licorice into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

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Abstract

The invention provides a preparation method of a bezoar antidote tablet. The bezoar antidote tablet is obtained by carrying out supercritical fluid extraction on the following raw herbal materials: 5g of bezoar, 50g of realgar, 200g of gypsum, 200g of rheum officinalem, 150g of scutellaria baicalensis, 100g of platycodon grandiflorum, 25g of borneol and 50g of liquorice, so that the content is greatly increased, and the dose is reduced. The invention also provides an application of the bezoar antidote tablet in preparation of a medicine for inhibiting the proliferation of a human nasopharyngeal carcinoma cell CNE-2Z.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Niuhuang Jiedu tablets. Background technique [0002] Niuhuangjiedu tablets are recorded in the Pharmacopoeia, the prescription is 5g of bezoar, 50g of realgar, 200g of gypsum, 200g of rhubarb, 150g of baicalensis, 100g of platycodon, 25g of borneol, 50g of licorice, the above eight flavors, realgar water fly into very fine powder; rhubarb is crushed into fine powder Grind bezoar and borneol finely; decoct the other four flavors such as Scutellaria baicalensis with water twice, 2 hours each time, combine the decoction, filter, concentrate the filtrate into a thick paste, add rhubarb and realgar powder, make granules, dry, and then add Calculus bezoar and borneol powder, mixed evenly, compressed into 1000 tablets (large tablets) or 1500 tablets (small tablets), or coated, to obtain. Can clear away heat and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/20A61P1/02A61P11/04A61P11/02A61P35/00A61K35/413A61K33/36A61K33/06A61K31/045
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH