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Preparation method and application of pseudo-ginseng injury tablets

A technology of notoginseng wounds and pills, which is applied in medical formulas, medical preparations containing active ingredients, antineoplastic drugs, etc. It can solve the problems of large dosage, backwardness, and many impurities for patients, and achieve the effect of reducing dosage

Active Publication Date: 2014-01-08
上海宝龙安庆药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Sanqishangyao Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product

Method used

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  • Preparation method and application of pseudo-ginseng injury tablets
  • Preparation method and application of pseudo-ginseng injury tablets

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Take 52.5g of Panax notoginseng, 52.5g of Aconiti (steamed), 23g of Artemisia spp., 1.05g of borneol, 492.2g of drynaria, 157.5g of safflower, 787.5g of elderberry, and 87.5g of red peony, and add them to CO2 supercritical extraction In the device, ethanol is used as entrainer, the entrainer accounts for 4% by volume of the total extraction solvent, extraction pressure is 15MPa, temperature is 30°C, CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take 52.5g of Panax notoginseng, 52.5g of Aconitum (steamed), 23g of Artemisia spp., 1.05g of borneol, 492.2g of drynaria, 157.5g of safflower, 787.5g of elderberry, and 87.5g of red peony, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take 52.5g of Panax notoginseng, 52.5g of Aconitum (steamed), 23g of Artemisia spp., 1.05g of borneol, 492.2g of drynaria, 157.5g of safflower, 787.5g of elderberry, and 87.5g of red peony, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

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Abstract

The invention provides a preparation method for pseudo-ginseng injury tablets. The pseudo-ginseng injury tablets are prepared by performing supercritical extraction on 52.5 g of pseudo-ginseng, 52.5 g of aconite (steamed), 23 g of short-pedicel aconite root, 1.05 g of borneol, 492.2 g of drynaria rhizome, 157.5 g of safflower, 787.5 g of elderberry and 87.5 g of red peony root serving as raw materials, so that the content of each raw material is greatly improved, and the dose is reduced. The invention also provides application of the pseudo-ginseng injury tablets in preparation of a medicament for inhibiting the cell proliferation of human histiocytic lymphoma U937.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a notoginseng tablet. Background technique [0002] Sanqishangyao Tablets are recorded in the Pharmacopoeia, and the prescription is 52.5g of Sanqi, Aconitum (steamed) 52.5g, Artemisia spp. 23g, Borneol 1.05g, Drynaria 492.2g, Safflower 157.5g, Elderberry 787.5g, Radix Paeoniae Rubra 87.5g, the above eight flavors, except borneol, three flavors such as Aconitum aconitum, Panax notoginseng, and Artemisia spp. are ground into fine powder; borneol is ground into fine powder; other four flavors such as drynaria are decocted twice, the first time for 2 hours, For the second 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.05 (80-90°C), let it stand, absorb the supernatant and concentrate it to a clear paste with a relative density of 1.40 (80-90°C); add Aconitum aconitu...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/20A61P35/00
Inventor 不公告发明人
Owner 上海宝龙安庆药业有限公司
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