Lossless method for quantitatively detecting blood glucose by utilizing Raman spectrum

A technology of Raman spectroscopy and quantitative detection, which is applied in the field of non-destructive quantitative detection of blood glucose without the need for blood sampling to quantitatively measure glucose concentration in skin blood by using Raman spectroscopy technology, which can solve the problems of large spectral differences, large interference, and low blood glucose concentration. To achieve the effect of overcoming signal strength drift

Inactive Publication Date: 2014-01-15
GUANGXI ACAD OF SCI
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Problems solved by technology

The main problems are: 1. The blood sugar concentration is very low, and the traditional physical means cannot accurately meet the clinical accuracy requirements; 2. The current non-destructive technical methods cannot obtain direct single information of blood due to skin or other interference, generally through mathematics The processing method is used to extract relevant information, resulting in large interference, insufficient stability, and inaccurate measurement; 3. Large differences in individual skin lead to large spectral differences, and there is no internal calibration reference index

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  • Lossless method for quantitatively detecting blood glucose by utilizing Raman spectrum
  • Lossless method for quantitatively detecting blood glucose by utilizing Raman spectrum
  • Lossless method for quantitatively detecting blood glucose by utilizing Raman spectrum

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specific example

[0022] The following is an example of using the method provided by the present invention to quantitatively measure blood glucose concentration.

[0023] The laser light emitted from the laser diode 1 is filtered by the interference filter 2, and reflected by the mirror 3 to the dichroic mirror 4. The function of the dichromatic mirror 4 is to reflect the laser light, and the Raman spectrum higher than the laser wavelength can pass through. The dichroic mirror 4 reflects the laser light to the reflection mirror 5, and the reflection mirror 5 guides the laser light into the lens 6, and the lens 6 focuses the laser light through the slide glass 7 and the skin into the blood vessel. The Raman spectrum excited at the laser focus passes through the slide glass 7, the lens 6, the mirror 5 and the dichroic mirror 4, passes through the bandpass (or notch) filter 9, enters the spectrometer 10, and is split by the spectrometer 10 , imaged on CCD11. The computer 12 connected with CCD11 r...

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Abstract

A lossless method for quantitatively detecting blood glucose by utilizing the Raman spectrum comprises the following steps that laser emitted by a semi-conductor diode transmits through skin by the adoption of a lens, the laser focuses into a blood vessel to obtain the Raman spectrum of blood, the characteristic peak of glucose and the characteristic peak intensity of hemoglobin which are obtained through the Raman spectrum are divided to obtain the relative intensity of the characteristic peak of the glucose, specific values of different blood glucose concentrations to the relative intensity of the characteristic peak of the glucose are calculated to obtain a relative intensity-concentration relation curve, and the curve serves as the basis of quantitative measurement of the blood glucose concentration; the relative intensity of the characteristic peak of the glucose in the Raman spectrum of the blood with unknown concentration is compared with the relative intensity-concentration relation curve to obtain the glucose concentration in the blood.

Description

Technical field [0001] The invention relates to a method for non-destructive quantitative detection of blood sugar, in particular to a method for quantitative determination of glucose concentration in skin blood by using Raman spectrum technology without blood sampling. The invention belongs to the technical field of Raman spectrum detection. Background technique [0002] At present, the detection method of blood sugar is generally carried out by blood sampling. In short, a certain amount of blood is drawn, and the concentration of glucose in the blood is detected by biological or physical methods. Among them, blood samples of a few microliters are taken for the least damage. , using enzymatic reaction to calibrate the concentration of blood sugar. At present, non-destructive detection methods have not been widely used in clinical practice. The main problems are: 1. The blood sugar concentration is very low, and the traditional physical means cannot accurately meet the cli...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1455
Inventor 姚辉璐何碧娟黎永青绍敬伟林漫漫梁建平李雪
Owner GUANGXI ACAD OF SCI
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