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Ceftazidine composition freeze-dried powder for injection

A technology of ceftazidime and freeze-dried powder injection, which is applied in the field of medicine and medicine manufacturing, and can solve problems such as weak resistance

Inactive Publication Date: 2014-01-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The difference is that it is effective against Pseudomonas aeruginosa, but less resistant to Gram-positive bacteria, Enterococcus, methicillin-resistant Staphylococcus, Listeria, Helicobacter, Clostridium difficile and Bacteroides fragilis (most strains) are resistant to this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, preparation of lyophilized powder injection of ceftazime composition for injection, in 1000 pieces.

[0029] 1. Prescription:

[0030] Ceftazidime 1000g

[0031] Chitosan Nanoparticles 800g

[0032] Water for injection 2000ml

[0033] 2. Preparation process:

[0034] The chitosan nanoparticle that weighs 800g is slowly added in the water for injection of 2000ml, stirs while adding, until dissolving.

[0035] Add 1000 g of ceftazidime and stir to dissolve until clear.

[0036] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to ceftazidime 1.0g per bottle to calculate the filling volume.

[0037] Fill according to the test requirements, put it into a freeze dryer after half-tamping, cool down ...

Embodiment 2

[0038] Embodiment 2, preparation of ceftazidime composition freeze-dried powder for injection, in 1000 pieces.

[0039] 1. Prescription:

[0040] Ceftazidime 1000g

[0041] Chitosan Nanoparticles 865g

[0042] Water for injection 2000ml

[0043] 2. Preparation process:

[0044] The chitosan nanoparticle that weighs 865g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0045] Add 1000 g of ceftazidime and stir to dissolve until clear.

[0046] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to ceftazidime 1.0g per bottle to calculate the filling volume.

[0047] Fill according to the test requirements, put it into a freeze dryer after half-tamping, cool down to -40°C, keep war...

Embodiment 3

[0048] Embodiment 3, preparation of lyophilized powder injection of ceftazidime composition for injection, in 1000 pieces.

[0049] 1. Prescription:

[0050] Ceftazidime 1000g

[0051] Chitosan Nanoparticles 757g

[0052] Water for injection 2000ml

[0053] 2. Preparation process:

[0054] The chitosan nanoparticle that takes by weighing 757g is slowly added in the water for injection of 2000ml, stirs while adding, until dissolving.

[0055] Add 1000 g of ceftazidime and stir to dissolve until clear.

[0056] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to ceftazidime 1.0g per bottle to calculate the filling volume.

[0057]Fill according to the test requirements, put it into a freeze dryer after half-tamping...

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PUM

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Abstract

The invention provides a ceftazidine composition freeze-dried powder for injection, and belongs to the field of medicine and medicine preparation technology. The ceftazidine composition freeze-dried powder comprises following raw material ingredients, by weight, 7.26 to 9.17 parts of ceftazidine, 5.78 to 7.67 parts of chitosan nanoparticle, and 81.38 to 87.10 parts of injection water. Advantages of the ceftazidine composition freeze-dried powder are that: 1) in vitro antibacterial activity spectrum is wider, antibacterial activity of ceftazidine on gram-negative bacteria is improved greatly; 2) the drug-loading nanoparticle can be swallowed by macrophages as a foreign matter, and is capable of reaching target sites, such as liver, spleen, lung, marrow and lymph, where reticuloendothelial systems are distributed intensively, or binding with target sites which possess ligands, antibodies, and enzyme substrates; 3) improvement of activity is capable of shortening medication cycle of patients, and reducing occurrence likelihood of adverse reaction caused by accumulation of ceftazidine; and 4) the chitosan nanoparticle can be used as a freeze-dried skeleton agent of the freeze-dried powder injection instead of mannitol, so that active effects of mannitol on human bodies are avoided.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a ceftazidime composition freeze-dried powder for injection. Background technique: [0002] Ceftazidime is a semi-synthetic third-generation cephalosporin, and its mechanism of action is similar to that of other cephalosporins. This product can inhibit the transpeptidation of transpeptidase in the last step of cross-linking in cell wall synthesis, so that cross-linking cannot be formed. Thereby affecting the synthesis of cell wall, leading to bacterial lysis and death. It is suitable for sepsis caused by sensitive Gram-negative bacilli, lower respiratory system infection, abdominal cavity and biliary system infection, complicated urinary tract infection and severe skin and soft tissue infection. [0003] Similar to other third-generation antibiotics, it has a broad response against both Gram-positive and Gram-negative bacteria. The difference is that ...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K47/36A61K9/19A61P31/04A61K31/546
Inventor 汪六一汪金灿查龙飞
Owner HAINAN WEI KANG PHARMA QIANSHAN
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