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Traditional Chinese medicine extract and its extraction method for promoting excretion of radionuclide in irradiated human body

A technology of radionuclide and extraction method, which is applied in the field of traditional Chinese medicine extract and its extraction for radionuclide-promoted excretion of irradiated human body. Trace element deficiency syndrome, less toxic and side effects

Active Publication Date: 2015-10-28
CHINA INST FOR RADIATION PROTECTION
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The hidden dangers of nuclear radiation at home and abroad show that the protection of the exposed personnel and the timely treatment of the wounded are the focus of medical rescue, and effective treatment drugs are the key point and the key to ensure the success of the treatment. Currently, effective anti-radiation stimulation is tested on mice. There are about 500 kinds of drugs produced, but mainly sodium carbonate, quinine, amino acids and aminoalkylphosphinic acid complexing agents, but no natural complexing drugs have been found, and some chemical drugs are anti-radiation through clinical trials. The potency is not high, the toxic and side effects are too large, and the effective time is short. The main reason is that the potency of chemically synthesized drugs on the human body is different from that on animals. For example, some complexes of uranium and plutonium are mostly sulfur-containing compounds. , some heterocyclic compounds and steroid hormones and other drugs, these drugs generally have relatively large side effects, such as catechols and cystamine hydrochloride commonly used in complexing plutonium can cause severe gastric mucosal irritation damage, and the nuclear While the content of toxin in the bone decreases, the content in the kidney increases instead
Some drugs such as estriol can cause atrophy of sexual organs, and some drugs are effective in a short period of time in the body, but ineffective after exposure to radiation, such as some aminothiol and tryptamine compounds

Method used

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  • Traditional Chinese medicine extract and its extraction method for promoting excretion of radionuclide in irradiated human body

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Embodiment Construction

[0020] The present invention will be described in detail below in conjunction with the accompanying drawings and implementation process.

[0021] The medicine to be protected in the present invention is the main extraction component of traditional Chinese medicine, tropolone. The content is 5%-30%. The main component, tropolone, has a complexing effect on radionuclides in the human body, and can be used as a radionuclide-expelling drug for the irradiated human body. Drugs for endogenous excretion or wound cleaning drugs for irradiated human body.

[0022] Such as figure 1 As shown, the extraction process and extraction method of extracting monotropolone compound from Chinese herbal medicine are as follows:

[0023] (S1) Prepare the wood flour passing through a 2mm sieve after pulverizing the orientalis or mahogany with a pulverizer;

[0024] (S2) Boil the wood flour with 10% sodium carbonate or 10% sodium acetate weak base solution, concentrate the boiled product, precipit...

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Abstract

The invention relates to a preparation technology of radioactive excretion promotion medicines and particularly relates to a traditional Chinese medicine extract for irradiated body radionuclide excretion promotion and an extraction method of the traditional Chinese medicine extract. The method comprises the following steps: with platycladus orientalis and rosewood core materials of cupressaceae as extracting raw materials, extracting with weak alkali water or alcohol, and recovering an extraction solvent, wherein the extraction components comprise tropolone, resins and volatile essential oil. The traditional Chinese medicine extract can be used for complexing excretion promotion medicines and wound-cleaning medicines of personnel suffering from radionuclide contamination and also can be applied to a clean recovery complexing agent in a radioactive experiment site.

Description

technical field [0001] The invention relates to the preparation technology of radioactive excretion-promoting medicine, in particular to a traditional Chinese medicine extract and its extraction method for irradiated human radionuclide-promoting excretion. Background technique [0002] The hidden dangers of nuclear radiation at home and abroad show that the protection of the exposed personnel and the timely treatment of the wounded are the focus of medical rescue, and effective treatment drugs are the key point and the key to ensure the success of the treatment. Currently, effective anti-radiation stimulation is tested on mice. There are about 500 kinds of drugs produced, but mainly sodium carbonate, quinine, amino acids and aminoalkylphosphinic acid complexing agents, but no natural complexing drugs have been found, and some chemical drugs are anti-radiation through clinical trials. The potency is not high, the toxic and side effects are too large, and the effective time is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/14A61P39/02
Inventor 高芬芳路晶占景明刘占旗闻建华池翠萍魏锦萍
Owner CHINA INST FOR RADIATION PROTECTION
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