Ultrafine powder piece of prepared rehmannia root, and preparation method and use thereof

A technology of ultra-fine powder and powder decoction pieces, which is applied in powder delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effects of reducing clinical use, saving medicinal resources, and fast speed

Active Publication Date: 2014-02-12
康美药业(昆明)种质资源有限公司
View PDF10 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] This method of preparing micropowder increases the process of high-temperature leaching. At the same time, in the process of leaching and filtering, many medicinal ingredients are filtered out, which makes the medicinal ingredients quite different from the original decoction pieces. This product may tend to be more traditional Chinese medicine. Micronized extract, not micronized decoction pieces, and the later ultrafine pulverization process also introduces the disadvantages of mechanical pulverization

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ultrafine powder piece of prepared rehmannia root, and preparation method and use thereof
  • Ultrafine powder piece of prepared rehmannia root, and preparation method and use thereof
  • Ultrafine powder piece of prepared rehmannia root, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1 Material pretreatment

[0046] 1.1 Material drying

[0047] Dry rehmannia glutinosa with vacuum microwave drying equipment, the microwave parameters are vacuum degree -0.70~-0.95MPa, microwave power 1~5KW, temperature 40~60°C, dry until the water content is below 5.5% by weight, and let it cool.

[0048] 1.2 Material crushing

[0049] The dried rehmannia glutinosa is pulverized into fine powder with a Cuting mill, sieved, and set aside.

[0050] 1.3 Initial homogenate

[0051] 1.3.1 Investigation of solid-liquid ratio

[0052] Mix Shudi fine powder with water at a weight ratio of 1:4, 1:6, 1:8, 1:10, and 1:12, adjust the speed of the high-shear emulsifier to "F" (25,000rpm), and mix well Slurry for 5 minutes, observe the state of the slurry and measure the particle size distribution to ensure that the particle size of the material after the initial homogenization is less than 50 μm. As a result, when the speed of the homogenizer is selected at a higher level "F", ...

Embodiment 2

[0081] Embodiment 2 and the comparison of dissolution rate and leaching rate of traditional decoction pieces

[0082] 1 Determination of the dissolution rate of verbascoside

[0083] 1.1 Method

[0084] According to the liquid phase condition method under the first part of the "Chinese Pharmacopoeia" 2010 edition, octadecylsilane bonded silica gel is used as filler; acetonitrile-0.1% acetic acid solution (16:84) is used as mobile phase; detection wavelength 334nm. The number of theoretical plates should not be less than 5000 based on the peak of verbascoside.

[0085] 1.2 Preparation of reference solution

[0086] Accurately weigh an appropriate amount of verbascoside reference substance, accurately weigh it, add mobile phase to make a solution containing 10 μg per 1 ml, and obtain it.

[0087] 1.3 Sample extraction

[0088]Precisely weigh about 2.5 g of common decoction pieces of Rehmannia glutinosa (content of verbascoside 0.026% by weight) and superfine powder decoct...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention provides an ultrafine powder piece of prepared rehmannia root. The granularity of the ultrafine powder piece of prepared rehmannia root is 1-10mum, the quantity of bacteria contained in the piece does not exceed 10000cfu/g, and the quantity of moulds or microzymes contained in the piece does not exceed 100cfu/g. The invention also provides a preparation method of the ultrafine powder piece of prepared rehmannia root, and an application of the ultrafine powder piece of prepared rehmannia root. The ultrafine powder piece of prepared rehmannia root satisfies microbial limit requirements of oral solid medicines, and the component dissolution rate and the component leaching rate of the ultrafine powder piece are greatly higher than that of a traditional piece; the preparation method of the ultrafine powder piece of prepared rehmannia root needs no ultralow temperature treatment process, no extraction and no high temperature treatment process, and the crushing process does not cause component damage or removal, so the preparation method is suitable for the industrial production; and the preparation method of the piece of prepared rehmannia root can realize a disinfection effect, is a cold sterilization technology, avoids the destroys of a high temperature to traditional Chinese medicinal components, and avoids chemical gas and radiation pollution by killing bacteria through a physical method.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to superfine powder decoction pieces of rehmannia glutinosa and its preparation method and application. Background technique [0002] Rehmannia glutinosa is processed from the roots of Rehmannia glutinosa Libosch., a plant of the Scrophulariaceae family, through wine stewing or steaming. Sweet in nature, slightly warm. Return liver, kidney channel. It has the effects of nourishing blood and nourishing yin, benefiting essence and filling marrow. For blood deficiency and chlorosis, palpitations, irregular menstruation, metrorrhagia, liver and kidney yin deficiency, soreness of the waist and knees, bone steaming and hot flashes, night sweats and nocturnal emission, internal heat quenching one's thirst, dizziness, tinnitus, premature graying of beard and hair. The main chemical components in Rehmannia glutinosa are polysaccharides, 5-hydroxymethylfurfural, amino acids, etc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/14A61P1/14A61P7/06A61P15/00A61P25/00A61P25/22A61P35/00A61P37/04A61P39/06
Inventor 陈有军吴小明陆珩程文胜马兴田许冬瑾向飞军
Owner 康美药业(昆明)种质资源有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap