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Preparation method for water-soluble compound of d-borneol and application of water-soluble compound

A water-soluble compound, dextroborneol technology, applied in chemical instruments and methods, active ingredients of hydroxyl compounds, washing compositions containing organic compounds, etc., can solve problems such as troublesome development and utilization, and achieve the effect of convenient processing

Active Publication Date: 2014-02-19
浙江天树龙脑林业科技开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the insoluble characteristics of d-borneol in water, unnecessary troubles have been brought to its development and utilization

Method used

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  • Preparation method for water-soluble compound of d-borneol and application of water-soluble compound

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Preparation of the water-soluble sodium salt of d-borneol

[0021] 1) Under a nitrogen atmosphere, add sodium metal to the ethanol solution of d-borneol in the reaction vessel, the molar ratio of d-borneol to sodium metal is 1:1.1, and slowly stir at a temperature of 25°C for 35 minutes, Fully react, stand still, overnight;

[0022] 2) Concentrate the mixture obtained in step 1) by filtration, wash with ethanol, dry, and collect the solid;

[0023] 3) Dissolving the solid obtained in step 2) in water, and then using an osmotic membrane for dialysis for 5 days, and then removing water under reduced pressure to obtain a water-soluble sodium salt of d-borneol.

Embodiment 2

[0024] Embodiment 2: Preparation of the water-soluble potassium salt of d-borneol

[0025] 1) Under a nitrogen atmosphere, add metal potassium to the tetrahydrofuran solution of d-borneol in a reaction vessel, the molar ratio of d-borneol to sodium metal is 1:1.2, and slowly stir at a temperature of 24°C for 30 minutes, Fully react, stand still, overnight;

[0026] 2) The mixture obtained in step 1) was concentrated by filtration, washed with ether, dried, and the solid was collected;

[0027] 3) Dissolving the solid obtained in step 2) in water, and then using an osmotic membrane for dialysis for 3 days, and then removing water under reduced pressure to obtain a water-soluble potassium salt of d-borneol.

Embodiment 3

[0028] Embodiment 3: Preparation of the water-soluble sodium salt of d-borneol

[0029] 1) Under a nitrogen atmosphere, add metallic sodium to the ether solution of d-borneol, the molar ratio of d-borneol to metallic sodium is 1:1.3, and slowly stir at a temperature of 28°C for 40 minutes to fully react and statically place overnight;

[0030] 2) The mixture obtained in step 1) was concentrated by filtration, washed with ether, dried, and the solid was collected;

[0031] 3) Dissolving the solid obtained in step 2) in water, and then dialysis with an osmotic membrane for 6 days, and then removing water under reduced pressure to obtain a water-soluble sodium salt of d-borneol.

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Abstract

The invention discloses a preparation method for a water-soluble compound of d-borneol and application of the water-soluble compound and belongs to the technical field of chemical engineering. The preparation method comprises the steps: 1) under a nitrogen atmosphere, adding sodium or potassium into an ether or ethanol solution of the d-borneol, performing slow stirring and full reaction, and stewing the solution overnight; 2) filtering and concentrating the mixture obtained in the step 1), washing and drying the mixture, and collecting solids; 3) dissolving the solids obtained in the step 2) into water, performing dialysis through a permeable membrane, and performing pressure reduction and water removal to obtain water-soluble sodium salt or potassium salt of the d-borneol. According to the preparation method, the d-borneol, namely natural borneol, can be prepared into the water-soluble sodium salt or the potassium salt of the d-borneol through the steps in the preparation method under the conditions, and the characteristic that the d-borneol cannot be dissolved into the water is changed, so that the obtained product is extremely easy to dissolve in water, and convenience is brought to the subsequent processing; furthermore, the invention also discloses novel application of the water-soluble sodium salt or the potassium salt of the d-borneol.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and in particular relates to a preparation method of a water-soluble compound of d-borneol and an application thereof. Background technique [0002] Cirmamonun Camphora is not only a precious and rare medicinal material, but also a high-grade spice, and an important chemical raw material. Known as plant gold, borneol camphor is native to the natural dipterocarp tree roots in Sumatra, Indonesia. It used to be the main source of borneol, but it has been nearly exhausted due to long-term over-harvesting. Borneo was first recorded in the Southern and Northern Dynasties, and has a history of more than two thousand years. In the classics of traditional Chinese medicine, borneol is called natural borneol. Because of its transdermal function, it is classified as an aromatic medicinal material. "Book of Materia Medica" says: borneol "its fragrance is the crown of a hundred medicines.". [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C35/30C07C29/68A61K31/045A61P31/04A61P27/02A23L2/52A23L2/38A23L1/30C11D9/50A21D13/00A21D2/14A21D13/06A21D13/80A23L33/105
CPCA21D2/145A23L2/52A61K31/045C11D9/26C07C29/70C07C35/30
Inventor 楼天伟辛文祥
Owner 浙江天树龙脑林业科技开发有限公司