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Bacterial strains belonging to the genus Bifidobacterium for the treatment of hypercholesterolemia

A technology for hypercholesterolemia and Bifidobacterium bifidum, applied in the direction of bacteria, microbial-based methods, preparations for in vivo tests, etc., can solve uncontrollable problems

Inactive Publication Date: 2018-02-13
PROBIOTICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This uncontrollable and unnecessary production of cholesterol represents a serious disadvantage

Method used

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  • Bacterial strains belonging to the genus Bifidobacterium for the treatment of hypercholesterolemia
  • Bacterial strains belonging to the genus Bifidobacterium for the treatment of hypercholesterolemia
  • Bacterial strains belonging to the genus Bifidobacterium for the treatment of hypercholesterolemia

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0059] Experimental part

[0060] The applicant has carried out intensive research activities for the selection of bacterial strains.

[0061] "In vivo" studies

[0062] A total of 32 rats were housed in cages. After a few days of adaptation to the diet (T0), all rats began to receive the same 100% hypercholesterolemia diet (100% hypercholesterolemizing diet). After 15 days of this diet (T15), the rats were randomly divided into 4 subgroups (8 rats per subgroup). Rats were initially treated differentially from T15 to T45. These treatments continued for 30 days until sacrifice (T45):

[0063] group 1 : 30% high cholesterol diet and Lactobacillus reuteri (Lactobacillus reuteri) NCIMB701359 (Kandler et al; 1982), 1 × 10 9 / day (reference). This strain is known to have the ability to lower cholesterol levels (ref).

[0064] group 2 : 30% high cholesterol diet and probiotic mixture [Bifidobacterium lactis MB2409DSM23733 (0.33×10 9 / day), Bifidobacterium breve MB113DS...

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Abstract

The present invention relates to selected strains of bacteria belonging to the genus Bifidobacterium for use in the treatment of hypercholesterolemia. In particular, the invention relates to a food composition or a supplement product or a medical device or a pharmaceutical composition comprising said bacterial strain, which is associated with cholesterols or phytocholesterols, and / or stanols or phytostanols and / or glucomannan and / or konjac gum and / or prebiotic fiber and / or fermented red rice and / or beta-glucan (from oats, oat bran, barley, barley bran) and / or A combination of Aloe arborescens gel in freeze-dried form.

Description

technical field [0001] The present invention relates to selected strains of bacteria belonging to the genus Bifidobacterium for use in the treatment of hypercholesterolemia. In particular, the present invention relates to a compound containing cholesterol or plant cholesterol, and / or stanols (stanols) or plant stanols, and / or glucomannan, and / or konjac gum, and / or prebiotic said bacterial strains in combination with metafibers, and / or fermented red rice, and / or beta-glucan (from oats, oat bran, barley, barley bran), and / or aloe vera gel in freeze-dried form food composition or supplement product or medical device or pharmaceutical composition. Background technique [0002] All cells of the body are known to synthesize cholesterol from acetyl-CoA, but most cholesterol is produced in the peroxisomes of liver cells, which transfer it to the blood for transport throughout the body. [0003] When we talk about "cholesterol" in medicine, we don't mean cholesterol as a chemical p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/745A23L33/135A61P3/06C12R1/01C12R1/13C12R1/225
CPCA23L29/25A23L33/105A23L33/135A23L33/21A61K35/745A61P3/06A61P43/00A23L33/195A61K2121/00
Inventor G·莫格纳G·P·斯特罗兹卢卡·蒙加
Owner PROBIOTICAL