Probe, probe head and device for measuring impedance of living body

Abstract

A probe for measuring the impedance of a living body comprises a probe rod 6, a probe guide sleeve 7, a pressure spring 8 and an insulating layer 9, wherein one end of the probe rod 6 is provided with an attaching face 10, the probe rod 6 is in slide fit with the probe guide sleeve 7 in the axial direction, one end of the pressure spring 8 abuts against the top wall of the probe guide sleeve 7, the other end of the pressure spring 8 abuts against the head portion of the probe rod 6, and the insulating layer 9 is arranged on the side wall of the probe rod 6. Four probes are regularly arranged, the probe guide sleeves 7 and the four probes are fixed together to form a probe head 4, the probe guide sleeves 7 in the probe head 4 are fixed to a probe head fixing device 3, one end of the probe head fixing device 3 is in slide fit with a slide shaft 2, one end of the slide shaft 2 is fixedly connected with a base 1, and therefore a device for measuring the impedance of the living body is formed. The probe rods are stretched out and drawn back due to relaxation of the pressure springs, and therefore the attaching faces of the four probe rods all make contact with the surface of tissue to be measured, the insulating layers can limit the largest contact electricity conduction area of the probe rods and the tissue to be measured, and data collection accuracy is improved.

Description

technical field [0001] The invention relates to a probe, a probe and a device for measuring the electrical impedance of isolated biological tissues, and relates to the field of biological electrical impedance measurement in biomedical engineering. Background technique [0002] Electrical impedance, as a basic physical parameter of biological tissue, has been widely concerned by biophysicists and physiologists for a long time. The patch clamp and voltage clamp techniques widely used in the field of electrophysiology are based on the principle of the electrical impedance effect of the cell membrane. Biological tissue is a kind of dielectric, and its electrical characteristics are worthy of further study. Early biophysics studies have shown that the difference in the electrical resistance characteristics of biological tissues in the DC state can be used to distinguish different tissues; what is more noteworthy is that the electrical impedance of biological tissues varies with ...

AI Technical Summary

Problems solved by technology

[0006] To measure the impedance spectrum of the tested biological tissue, keep the physiological indicators of the tested tissue in a stable state, and not allow secretions and blood to contaminate the tested tissue, and Do not rinse with water, so as not to affect the accuracy of the measurement data

[0007] In the prior art, there is a measuring box for the dielectric properties of biological isolated tissues, but it takes time to slice the measured tissue during operation, which destroys the structural properties of biological tissues, and takes too long. The complex impedance has changed, which interferes with the accuracy of the measurement results

[0008] In the prior art, there are probes for measuring the impedance of human or animal tissue, but it does not take into account that the surface of the sliced ​​biological tissue structure is not in a completely flat state, and that various tissues contract differently when pressure is applied to the probe during measurement. For example, breast cancer tissue is produced by cancer cells phagocytizing the surrounding normal cells. The center of the tissue has the highest density and collapses inward. When the tissue is sliced, it cannot be completely flat, resulting in poor or incomplete contact between the electrode and the biological tissue under test. The measurement data is inaccurate or the measurement is unsuccessful; and increasing the pressure of the electrode facing the biological tissue under test will cause residual secretions or blood overflow in the tissue to interfere with the measurement

[0009] In addition, the conductivity of the probe is often also affected by the size of the conductive area of ​​the contact surface between the probe and the tissue under test. After the probe is pressed, the tissue under test deforms, not only the attached surface becomes a conductive surface, but the probe near the attached surface The side of the needle also becomes a conductive surface due to contact with the measured tissue, so that the acquired data is affected by the change of the conductive surface

That is to say, after the existing probe is pressed, the change of the conductive area between the probe and the tissue under test affects the accuracy of data collection.

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