Preparation method of pefloxacin mesylate
A technology of pefloxacin mesylate and methanesulfonic acid, which is applied in the field of preparation of pefloxacin mesylate synthesized from solid formaldehyde, can solve the problems of uneconomical, reduced product yield, time-consuming and labor-intensive problems
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example 1
[0009] Example 1: Add 95g of formic acid and 14g of solid formaldehyde into a 500ml reaction flask, add 98g of norfloxacin several times under stirring, slowly raise the temperature to 72°C and maintain reflux for 1.5h after 1h, then raise the temperature to 95°C and maintain reflux for 6.5h; After evaporating to dryness under reduced pressure, add water and distill 4 times, cool down to 25~30°C, add 450g of 83% ethanol, add 32.4g of methanesulfonic acid under stirring, heat up to 75°C and reflux for 1.5h, slowly cool down to 0-3°C and suction filter; Add 83% ethanol to the obtained product, raise the temperature until the material liquid is clear, add 5 g of medicinal carbon, heat filter after 1 hour, slowly cool the filtrate to 0-3°C for suction filtration, and dry at 40°C to obtain off-white crystalline powder 133g, the yield is 93.2%, the moisture content is 7.4%, and the pefloxacin mesylate content is 99.87%.
example 2
[0010] Example 2: Add 85g of formic acid and 13.9g of solid formaldehyde into the reaction kettle, add 94g of norfloxacin several times under stirring, slowly raise the temperature to 71°C and maintain reflux for 1h after 1h, raise the temperature to 96°C and maintain reflux for 6.5h; After pressure-evaporating to dryness, add water to distill three times, cool down to 25-30°C, add 450g of 83% ethanol, add 32.3g of methanesulfonic acid under stirring, heat up to 72°C and reflux for 1.5h, slowly cool down to 0-3°C and suction filter; Add 83% ethanol to the product, raise the temperature until the material liquid is clear, add 5 g of medicinal carbon, heat filter after 1 hour, slowly cool the filtrate to 0-3°C for suction filtration, and dry at 40°C. 123 g of off-white crystalline powder was obtained with a yield of 89.7%, a water content of 7.2%, and a pefloxacin mesylate content of 99.97%.
example 3
[0011] Example 3: Add 100g of formic acid and 20g of solid formaldehyde into the reaction kettle, add 100g of norfloxacin several times under stirring, slowly raise the temperature to 72°C and maintain reflux for 1h after 1h, raise the temperature to 91°C and maintain reflux for 6.5h; reduce pressure After evaporating to dryness, add water to distill 3 times, cool down to 25~30°C, add 450g of 83% ethanol, add 38g of methanesulfonic acid under stirring, heat up to 70°C and reflux for 1.5h, slowly cool down to 0-3°C and suction filter; the obtained product Add 83% ethanol, raise the temperature until the material liquid is clear, add 5 g of medicinal carbon, heat filter after 1 hour, slowly cool the filtrate to 0-3 °C for suction filtration, and dry at 40 °C. 133 g of off-white crystalline powder was obtained with a yield of 91.8%, a moisture content of 7.5%, and a pefloxacin mesylate content of 99.85%.
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