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Risperidone orally-disintegrating tablet

A technology for risperidone orally disintegrating tablets and risperidone, which is applied in the field of chemical pharmacy, can solve problems such as difficulty in swallowing and inconvenience for patients to use, and achieve the effects of rapid disintegration, stable quality and excellent taste.

Inactive Publication Date: 2014-04-30
SHANGHAI TIANLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As is well known, these preparations must be taken orally as a whole when used, and there are defects such as inconvenient use and difficulty in swallowing for patients.
For patients who need to take medicine for a long time, there are obvious problems of medication compliance

Method used

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  • Risperidone orally-disintegrating tablet
  • Risperidone orally-disintegrating tablet
  • Risperidone orally-disintegrating tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029] Preparation: Pass all raw and auxiliary materials through 80-100 mesh sieves, thoroughly mix risperidone and other excipients, sieve through No. 14-18 sieves, add flow aid, press into tablets, and pack after passing the inspection.

Embodiment 2

[0031]

[0032] Preparation: Pass all raw and auxiliary materials through 80-100 mesh sieves, thoroughly mix risperidone and other excipients, sieve through No. 14-18 sieves, add flow aid, press into tablets, and pack after passing the inspection.

Embodiment 3

[0034]

[0035] Preparation: Pass all raw and auxiliary materials through 80-100 mesh sieves, thoroughly mix risperidone and other excipients, sieve through No. 14-18 sieves, add flow aid, press into tablets, and pack after passing the inspection.

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PUM

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Abstract

The invention provides a risperidone orally-disintegrating tablet. The risperidone orally-disintegrating tablet contains a physiologically effective amount of risperidone and a necessary pharmaceutically-suitable excipient. The risperidone orally-disintegrating tablet has content of 5-10wt%. The pharmaceutically-suitable excipient is a mixture comprising a filler, an odor mask agent, a disintegrating agent, a surfactant, a binder, a lubricant and a flow promoter. The risperidone orally-disintegrating tablet has the advantages of fast disintegration rate, excellent taste, stable quality and reliable curative effects and can improve patient compliance.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to a risperidone orally disintegrating tablet and a preparation method thereof. Background technique [0002] Risperidone, its chemical name is: 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 , 8,9-tetrahydro-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one, this product is a derivative of benzisoxazole, a new generation of antipsychotics. Its active ingredient, risperidone, is a selective monoaminergic antagonist with unique properties. It has high affinity to serotonergic 5-HT2 receptors and dopamine D2 receptors. Risperidone also binds to adrenergic receptors, and with lower affinity to H1-histaminergic receptors and α2-adrenergic receptors. Risperidone does not bind to cholinergic receptors. Risperidone is a potent D2 antagonist that can improve the positive symptoms of schizophrenia, but it causes less motor depression and catalepsy than classical anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/519A61P25/18
Inventor 丁杰
Owner SHANGHAI TIANLONG PHARMA
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