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Method for preparing eleutheroside and eleutheroside preparation, and application thereof

A technology of total glucosides of Acanthopanax senticosus and Acanthopanax senticosus, applied in the directions of antitoxins, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problems of low total yield of Acanthopanax senticosus, low content of total glucosides of Acanthopanax senticosus, etc., and achieve solvent recovery Easy, lower production cost, low production cost effect

Active Publication Date: 2014-04-30
北京度衡之道医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total glucoside content of Acanthopanax senticosus in the extract obtained by the two processes is not high, and the total yield of Acanthopanax senticosus in the extract obtained by the purification process is low

Method used

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  • Method for preparing eleutheroside and eleutheroside preparation, and application thereof
  • Method for preparing eleutheroside and eleutheroside preparation, and application thereof
  • Method for preparing eleutheroside and eleutheroside preparation, and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Acanthopanax senticosus is crushed into 1 kg of coarse particles of 12-20 mesh, extracted with water, extracted for 1 hour, extracted once, concentrated under reduced pressure, concentrated until the relative density is 1.10-1.15 under the condition of 55°C; the obtained extract (i.e. concentrated The mass fractions of syringin, eleutheroside E and isoxapyridine in liquid) were 0.401%, 0.271% and 0.031%, respectively.

Embodiment 2

[0040] Acanthopanax senticosus is crushed into 1kg of 12-20 mesh coarse particles, extracted with 50% methanol or ethanol, extracted for 1 hour, extracted once, concentrated under reduced pressure, and concentrated until the relative density is 1.10-1.15 at 55°C; the obtained extracted The mass fractions of syringin, eleutheroside E and isoxapyridine in the product (ie concentrated solution) are 0.612%, 0.383% and 0.082%, respectively.

Embodiment 3

[0042] Acanthopanax senticosus is crushed into 1kg of coarse particles of 12-20 mesh, extracted with 75% methanol or ethanol, extracted for 1 hour, extracted once, concentrated under reduced pressure, and concentrated to a relative density of 1.10-1.15 at 55°C; the obtained extracted The mass fractions of syringin, eleutheroside E and isoxapyridine in the product were 0.582%, 0.332% and 0.073%, respectively.

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Abstract

The invention discloses a method for preparing eleutheroside. The method comprises the following steps: (1) crushing acanthopanax root into coarse particles of 12-20 meshes, extracting 1-3 times with water or less than 95 percent ethanol, for 1-2 hours each time, combining the extracts, concentrating at reduced pressure until the relative density is 1.10-1.15 at 55 DEG C to obtain a concentrate, and investigating with 3 index components in the acanthopanax root; (2) performing resin column chromatography on the concentrate: washing with water, and eluting with 8-10BV of 30-70 percent ethanol or methanol as eluent, combining the eluents, concentrating at reduced pressure until the eluents are dried, and crushing, wherein the resin column is HP-20, D-101, AB-8 or NKA-9. The product prepared by the method for preparing eleutheroside is high in active component content, high in purity and low in cost.

Description

technical field [0001] The invention relates to a process for extracting traditional Chinese medicine components from Chinese medicinal materials, in particular to a preparation method for extracting the effective components of Acanthopanax senticosus, total glycosides of Acanthopanax senticosus and total glycosides of Acanthopanax senticosus. Background technique [0002] Acanthopanax is the dry root, rhizome or stem of Acanthopanax Araliaceae, which has the functions of dispelling wind-dampness, strengthening muscles and bones, and activating blood vessels; Weakness, bruises, fractures, edema, beriberi, wet itching in the vagina. Pharmacological studies have shown that Acanthopanax has anti-fatigue, anti-cancer and anti-aging effects. The main active ingredients contained in Acanthopanax are syringin, eleutheroside E, and eleutheroside B, which are collectively called eleutherosides, of which syringoside and eleutheroside E are relatively high. as its main medicinal ingr...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61P39/00A61P25/20A61P1/14A61P29/00
Inventor 傅宏征
Owner 北京度衡之道医药科技有限公司
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