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Medicine for radiodermatitis and preparation method thereof

A radiodermatitis and drug technology, applied in the field of medicine, can solve the problems of patient suffering and poor preventive effect, and achieve the effects of good curative effect, short course of treatment and convenient use.

Active Publication Date: 2014-05-07
金乡县化雨镇卫生院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, western medicines mainly include triethanol cream (Biafine), sucralfate ointment, corticosteroids (such as mometasone furoate, hydrocortisone, dicaine hydrochloride, chlorhexidine), vitamin B 12 , these drugs have a certain therapeutic effect on skin ulcers caused by radiation, but these drugs generally have a better therapeutic effect and a poor preventive effect. Wait until the patient suffers from radiation dermatitis before treatment, the patient is more painful

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] prescription:

[0042] Forsythia 15g, Andrographis paniculata 10g, Senecio 15g, Sophora flavescens 15g, Diding 15g, Sikuwa 15g, Tobacco leaf 15g, Duckweed 10g, Cnidium 10g, Cortex Phellodendri 10g, Lismodium 15g, Salvia miltiorrhiza 20g, Danpi 15g, Radix Paeoniae Rubra 15g, Leech 6g, Codonopsis 30g, Menthol 2g.

[0043] Preparation

[0044] (a) Weigh the API according to the weight ratio;

[0045] (b) Menthol is crushed into fine powder, sieved, and set aside;

[0046] (c) Add water to decoct the other raw materials for 2 times. For the first time, add water 8 times the weight of the drug, decoct for 2 hours, add water 6 times the weight of the drug for the second time, and decoct for 1.5 hours; combine the decoction , filtered, the filtrate was concentrated at 60°C to a clear paste with a density of 1.08-1.12, added to a Diaion HP-10 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the column volume eluate, and recovered under reduced ...

Embodiment 2

[0049] prescription

[0050] Forsythia 13g, Andrographis paniculata 12g, Senecio 13g, Sophora flavescens 17g, Diding 13g, Four tiles 17g, Tobacco leaves 13g, Duckweed 12g, Cnidium 8g, Phellodendron 12g, Lianmo grass 13g, Salvia 22g, Danpi 13g, Radix Paeoniae Rubra 17g, Leech 4g, Codonopsis 35g, Menthol 1.5g.

[0051] Preparation

[0052] (a) Weigh the API according to the weight ratio;

[0053] (b) Menthol is crushed into fine powder, sieved, and set aside;

[0054] (c) Add water to decoct the other raw materials for 2 times, add water 7 times the weight of the drug for the first time, decoct for 1.5 hours, add water 5 times the weight of the drug for the second time, decoct for 1 hour; combine the decoction , filtered, the filtrate was concentrated at 60°C to a clear paste with a density of 1.08-1.12, added to a Diaion HP-10 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the column volume eluate, and recovered under reduced pressure Ethano...

Embodiment 3

[0057] prescription

[0058] Forsythia 17g, Andrographis paniculata 8g, Senecio 17g, Sophora flavescens 13g, Diding 17g, Four tiles 13g, Tobacco leaves 17g, Duckweed 8g, Cnidium 12g, Phellodendron 8g, Lianmo grass 17g, Salvia 18g, Danpi 17g, Radix Paeoniae Rubra 13g, Leech 8g, Codonopsis 25g, Menthol 2.5g.

[0059] Preparation

[0060] (a) Weigh the API according to the weight ratio;

[0061] (b) Menthol is crushed into fine powder, sieved, and set aside;

[0062] (c) Add water to decoct the other raw materials twice, add 9 times the weight of the medicine for the first time, decoct for 2.5 hours, add water 7 times the weight of the medicine for the second time, decoct for 2 hours; combine the decoction , filtered, the filtrate was concentrated at 60°C to a clear paste with a density of 1.08-1.12, added to a Diaion HP-10 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the column volume eluate, and recovered under reduced pressure Ethanol unt...

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to a medicine for radiodermatitis and a preparation method thereof. The medicine for radiodermatitis disclosed by the invention is prepared from the following traditional Chinese medicinal materials in parts by weight: 11-19 parts of fructus forsythiae, 6-14 parts of common andrographis herb, 11-19 parts of groundsel, 11-19 parts of radix sophorae flavescentis, 11-19 parts of bunge corydalis herb, 11-19 parts of herba chloranthi serrati, 11-19 parts of tobacco, 6-14 parts of duckweed, 6-14 parts of fructus cnidii, 6-14 parts of golden cypress, 11-19 parts of longtube ground ivy herb, 15-25 parts of the root of red-rooted salvia, 11-19 parts of the root bark of the peony tree, 11-19 parts of radix paeoniae rubra, 3-9 parts of leech, 20-40 parts of codonopsis pilosula, and 1-3 parts of menthol. The medicine disclosed by the invention has the better effect of preventing radiodermatitis; pain of patients suffered from radiotherapy is greatly relieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for radiation dermatitis and a preparation method thereof. Background technique [0002] Radiation therapy is one of the important means of comprehensive tumor treatment, and more than 70% of tumor patients have been treated with radiation therapy. As the dose of radiotherapy gradually increases, the radiation will cause certain damage to the skin in the irradiation field, causing radiation dermatitis. Especially in recent years, with the use of thermoplastic film for body position fixation, the application of new radiotherapy technologies such as IMRT radiotherapy, and the widespread development of simultaneous radiotherapy and chemotherapy, the incidence of radiation dermatitis has been increasing. [0003] Radiation dermatitis refers to dermatitis caused by various types of rays, including rays, particles, electrons, neutrons and protons. The depth an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K9/12A61P17/16A61K31/045A61K35/62
Inventor 李伟
Owner 金乡县化雨镇卫生院
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