Method for preparing N,N-dimethylacetylamide
A technology of dimethylacetamide and methylacetamide, which is applied in the field of preparation of organic solvent N,N-dimethylacetamide, can solve the problems of high requirements for reaction conditions, high cost, and long reaction process, and avoid The effect of environmental pollution and short process
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Embodiment 1
[0014] A preparation method of N,N-dimethylacetamide, weighing 10g of formaldehyde, 23g of formic acid, 5g of catalyst and 38g of water into the reactor, maintaining 60°C, stirring vigorously for 1h;
[0015] Add 24g of N-methylacetamide dropwise at a rate of 0.5d / s with a constant pressure dropping funnel, and maintain the reaction at 50°C for 2h;
[0016] The reaction solution was centrifuged at 3000 rpm for 30 minutes; filtered under reduced pressure with qualitative filter paper for 30 minutes, the resulting filtrate was distilled at -0.1MPa, 100°C for 5 hours under reduced pressure, and the fraction at 164-166°C was collected to obtain N,N-dimethylacetamide .
Embodiment 2
[0018] Yet another method for preparing N,N-dimethylacetamide. Weigh 10g of formaldehyde, 22g of formic acid, 5g of catalyst and 64g of water into the reactor, maintain 65°C, and vigorously stir for 1.5h;
[0019] Add 24g of N-methylacetamide dropwise at a rate of 0.5d / s with a dropping funnel, and maintain the reaction at 55°C for 3h;
[0020] The reaction solution was centrifuged at 3000 rpm for 30 minutes; filtered under reduced pressure with qualitative filter paper for 30 minutes, the resulting filtrate was distilled at -0.1MPa, 105°C for 6 hours under reduced pressure, and the fraction at 164-166°C was collected to obtain N,N-dimethylacetamide .
Embodiment 3
[0022] Weigh 10g of formaldehyde, 21g of formic acid, 5g of catalyst and 106g of water into the reactor, maintain 70°C, and vigorously stir for 2h;
[0023] Add 25g of N-methylacetamide dropwise at a rate of 0.5d / s with a dropping funnel, and maintain the reaction at 60°C for 4h;
[0024] The reaction solution was centrifuged at 3000 rpm for 30 minutes; filtered under reduced pressure with qualitative filter paper for 30 minutes, the obtained filtrate was distilled at -0.1MPa, 110°C for 3 hours under reduced pressure, and the fraction at 164-166°C was collected to obtain N,N-dimethylacetamide .
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