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Application of recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure

An immunomodulatory protein, a technology for chronic heart failure, which is applied in the application field of recombinant Ganoderma lucidum immunomodulatory protein (rLZ-8) in the preparation of drugs for the treatment of chronic heart failure, and can solve problems such as different clinical effects

Inactive Publication Date: 2014-05-28
张喜田 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3) β-receptor blockers, β-receptor blockers treat the pathophysiological basis of CHF - reduce myocardial oxygen consumption and improve cardiac function: However, different β-receptor blockers may have different effects on heart failure patients clinical effect
Receptor blockers are not indicated for acute heart failure and should only be used in stable conditions

Method used

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  • Application of recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure
  • Application of recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure
  • Application of recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the establishment of heart failure animal model

[0037] 1.1 Experimental method:

[0038] 1.1.1 Experimental materials and reagents

[0039] rLZ-8, doxorubicin hydrochloride, normal saline, disposable 1mL syringe, Shengmai injection, rat feed, litter.

[0040] 1.1.2 Instruments and equipment

[0041] Incandescent lamp, rat breeding cage, electronic balance, 4°C refrigerator, two-person ultra-clean workbench, ordinary optical inverted microscope.

[0042] 1.1.3 Experimental animals

[0043] Wistar rats, female, weighing 200-240 g, were provided by the Experimental Animal Center of Jilin University (Certificate No.: Yidongzi No. 10-5112).

[0044] 1.2 Establishment of rat heart failure model

[0045] Choose healthy and flexible Wistar rats, female, weighing 200-240g, SPF grade, refer to Teraoka's method, and give doxorubicin hydrochloride (diluted with normal saline) intraperitoneally to the rats in all groups except the blank group, the injection do...

Embodiment 2

[0046] Example 2: Therapeutic effect of rLZ-8 on rat chronic heart failure model

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Abstract

The invention relates to an application of a recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure. According to the invention, a rat cardiac failure model is established by intraperitoneal injection of adriamycin amycin (ADR) to study the curative effect of rLZ-8 to chronic cardiac failure. Experimental research results show that rLZ-8 can remarkably improve the cardiac function of the rat cardiac failure model, reduce the rate of myocardial apoptosis, reduce expression of relevant apoptin in myocardial cells (caspase3 and caspase9) and increase the survival rate of rats with chronic heart failure.

Description

technical field [0001] The present invention relates to the application of recombinant Ganoderma lucidum immunoregulatory protein (rLZ-8) in the preparation of drugs for the treatment of chronic heart failure, in particular to the establishment of rat models of chronic heart failure, the design of treatment procedures and the statistical analysis of treatment results, and involves rat myocardial Detection of cells and related proteins, focusing on the application of recombinant Ganoderma lucidum immunomodulatory proteins in the treatment of chronic heart failure models in rats. Background technique [0002] Chronic heart failure (CHF) is the most common form of heart failure. It is the end stage of the development of various cardiovascular diseases such as coronary heart disease, cardiomyopathy, hypertension, and valvular heart disease, and it is also the leading cause of death. With the aging of the population and the improvement of the diagnosis and treatment system for ac...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61P9/04
CPCA61K36/074A61K38/168A61P9/04
Inventor 孙非梁重阳张喜田
Owner 张喜田
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