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Application of 20(R)-ginsenoside Rg3 in preparation of medicines for treating dysmenorrhea

A technology of ginsenosides and drugs, applied in the field of medicine, can solve problems such as unsatisfactory effective rates, threats to patients' health, neurological disorders, etc., and achieve the effects of safe clinical use, relieving dysmenorrhea pain, and less toxic and side effects

Active Publication Date: 2014-06-11
富力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term dysmenorrhea without timely treatment, or dependence on painkillers, will pose a certain threat to the patient's health, and even cause infertility in some people
[0009] At present, the drugs for the treatment of dysmenorrhea are mainly prostaglandin synthase inhibitors, steroidal hormone contraceptives, gonadotropin-releasing hormone agonists, β-receptor agonists, calcium channel blockers, leukotriene inhibitors and vasopressors. Among them, non-steroidal anti-inflammatory analgesics are the first choice of clinical medication for patients with dysmenorrhea, but the effective rate is not satisfactory, and it is often accompanied by gastrointestinal irritation, liver and kidney dysfunction and nerve dysfunction. Adverse reactions such as dysfunction, causing additional pain to patients

Method used

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  • Application of 20(R)-ginsenoside Rg3 in preparation of medicines for treating dysmenorrhea
  • Application of 20(R)-ginsenoside Rg3 in preparation of medicines for treating dysmenorrhea
  • Application of 20(R)-ginsenoside Rg3 in preparation of medicines for treating dysmenorrhea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 Rg3 cream

[0053] 1. Prepare raw materials according to the following ratio

[0054] 1) Prepare the raw materials of part A according to the ratio:

[0055]

[0056]

[0057] 2) Prepare the raw materials of Part B according to the ratio as follows:

[0058]

[0059] 2. Mix the raw materials of parts A and B respectively under stirring, heat and keep them at 70°C. After stirring evenly, add the mixed raw materials of part B to the raw materials of part A while stirring while keeping the temperature at 70°C. After stirring evenly, add deionized water to 100%, and cool to room temperature to prepare Rg3 topical cream.

Embodiment 2

[0060] Embodiment 2 Rg3 gel

[0061] 1. Prepare raw materials according to the following ratio

[0062]

[0063] 2. Add carbomer to deionized water, stir and swell, add ginsenoside Rg3, EDTA-Na2, essence, propylparaben, methylparaben, stir evenly, and use a mass percentage concentration of 10 % sodium hydroxide solution to adjust the pH of the mixed solution to 6 (pH 5-7 is also applicable to the present invention), stir evenly, and add deionized water to 100%.

Embodiment 3

[0064] Example 3 Rg3 plaster

[0065] 1. Prepare raw materials according to the following ratio

[0066]

[0067]

[0068] 2, ginsenoside Rg3 is mixed with a small amount of water, then add EDTA-Na After dissolving, be that the pH of 10% sodium hydroxide solution regulation mixing solution is 6 (pH is that 5~7 is also applicable to the present invention) with mass percent concentration ), then add essence, propylparaben, and methylparaben under stirring state, mix well and add to acrylic resin paste base, add deionized water to 100%, mix well, and spread on the back Plaster made of lined non-woven fabric.

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Abstract

The invention discloses a novel application of 20(R)-ginsenoside Rg3 in preparation of medicines for preventing and treating dysmenorrhea. Tests show that the 20(R)-ginsenoside Rg3 is significant in treating effects for the dysmenorrhea, quick in effectiveness, low in toxic and side effects, safe, efficient, stable, simple in preparation process, suitable for industrial production and prone to popularization. The application provides a novel medicine source for preventing and treating the dysmenorrhea and complications thereof.

Description

technical field [0001] The invention relates to the field of medicine, and relates to a drug or health food for preventing, alleviating and / or treating dysmenorrhea, and in particular to an application of traditional Chinese medicine ginseng extract in medicine or health food for preventing, alleviating and / or treating dysmenorrhea. Background technique [0002] Dysmenorrhea, or menstrual pain, is one of the most common symptoms in gynecological patients. Many women experience mild discomfort during their periods, but dysmenorrhea is when menstrual pain interferes with normal activities and requires medication. Periodic menstrual pain is common and occurs during most menstrual cycles. The pain is often cramping with low back pain, nausea, vomiting, headache, or diarrhea. [0003] Dysmenorrhea can be divided into primary dysmenorrhea and secondary dysmenorrhea. Primary dysmenorrhea is cyclic menstrual pain without organic disease, whereas secondary pain is often seen with ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P15/00A61P29/00A23L1/29A23L33/00
Inventor 富力王凯乾鲁明明王典仁柳杨刘正贤鲁岐刘国友周庆峰盖鑫
Owner 富力