A kind of preparation method of chitosan hydrochloride calcium hemostatic powder

Abstract

The invention discloses chitosan hydrochloride calcium styptic powder and a preparation method thereof. The preparation method comprises the following steps: by taking chitin as a raw material, carrying out a deacetylation reaction, washing, drying and smashing and sieving to prepare chitosan with a certain degree of deacetylation; then, uniformly mixing chitosan, a calcium chloride aqueous solution and an organic solvent to fully swell chitosan; adding hydrochloric acid and stirring so that the mixture reacts uniformly; and finally, filtering, washing, drying, smashing, packaging and sterilizing to prepare a finished product of chitosan hydrochloride calcium styptic powder. The chitosan hydrochloride calcium styptic powder prepared by the method can take styptic effect in many ways, can remarkably shorten the blood coagulation time, and has the effects of resisting bacteria, relieving pains and accelerating wound healing. Compared with the conventional preparation methods, the method has the advantages of simplicity and convenience in operation, stable process, high yield, low cost and mild reaction condition, and can better maintain the advantages of chitosan molecular parameters.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of chitosan hydrochloride calcium hemostatic powder. Background technique [0002] Chitosan is a kind of natural macromolecular alkaline polysaccharide, which has the advantages of abundant natural sources, good stability, good biocompatibility, biodegradability, safety and non-toxicity, broad-spectrum antibacterial, etc., and is suitable for development as a biomedical material. Many functions of chitosan are closely related to its water solubility and positive charge. Chitosan can react with organic or inorganic acids to form salts, which can be used to promote wound healing and hemostatic materials. Existing a variety of simple chitosan hemostatic agents, such as chitosan sponge, chitosan gel, chitosan dry powder, chitosan hemostatic bandage, etc., have been applied, but the simple chitosan hemostatic products promote The process of forming...

AI Technical Summary

Problems solved by technology

Our experimental research shows that the calcium chitosan prepared by this method has some defects, such as: due to the large difference in the density of inorganic salts such as chitosan and calcium chloride, the calcium content of the product is not uniform; the density of chitosan is small and Insoluble in water makes its adhesion poor; calcium adsorption reaction mostly occurs on the surface of chitosan particles, the adsorption rate is greatly affected by particle size, and the uniformity is also affected