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Mangiferin injection and preparation method thereof

A technology of glycoside injection and mangiferin, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor solubility of mangiferin, achieve improved solubility, stable quality, Ease of preparation

Inactive Publication Date: 2014-07-23
邓家刚 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a mangiferin injection and its preparation method, aiming to solve the problem of poor solubility of mangiferin by selecting a suitable solvent and proportioning to make a suitable injection

Method used

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  • Mangiferin injection and preparation method thereof
  • Mangiferin injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0013] Mix 45g of mangiferin powder, 600ml of polyethylene glycol 400, 150ml of water and 250ml of propylene glycol, and shake to dissolve at 105°C under airtight conditions to obtain mangiferin injection 1.

Embodiment 2

[0015] Mix 45g of mangiferin powder, 680ml of polyethylene glycol 400, 170ml of water and 150ml of propylene glycol, and shake to dissolve at 105°C under airtight conditions to obtain mangiferin injection 2.

Embodiment 3

[0017] Mix 45g of mangiferin powder, 760ml of polyethylene glycol 400, 190ml of water and 50ml of propylene glycol, and shake to dissolve at 105°C under airtight conditions to obtain mangiferin injection 3.

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Abstract

The invention provides a mangiferin injection and a preparation method thereof. The preparation method includes the steps of mixing mangiferin as a bulk drug, propylene glycol as an auxiliary material, PEG400 and water, carrying out a shaking operation for dissolving at 105 DEG C under a sealed condition, and inspecting the injection by clarity inspection and pyrogen inspection. The mangiferin injection is stable in quality. Content and clarity of the injection meet requirement. The content of the mangieferin can reach more than 4.0% and the solubility of the mangiferin is significantly enhanced (the solubility of the mangiferin in water is about 0.10 mg / ml and the solubility of the mangiferin in the injection is increased by 4000 times). The preparation method is simple in process and is easy to operate.

Description

technical field [0001] The invention belongs to the field of injection medicaments, in particular to a mangiferin injection and a preparation method thereof. Background technique [0002] Mangiferin (Mangiferin) is the main active ingredient of Mangifer a indica L leaf, also known as mangiferin, Zhimuning, is a natural polyphenolic compound extracted from Liliaceae Anemarrhena, molecular formula C 19 h 18 o 11 , molecular weight 422, its structural formula is as shown in formula 1 below: [0003] [0004] Mango leaf is a commonly used medicinal material in Guangxi, which is recorded in the 1990 edition of "Guangxi Medicinal Material Standards", and has various physiological activities and pharmacological effects. Mangiferin has the functions of relieving cough, eliminating phlegm, relieving asthma, anti-inflammation, immunity, protecting liver and gallbladder, anti-virus, anti-tumor, and antibacterial. Mango leaves have the advantages of wide distribution, rich medici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/352A61K47/34A61K47/10
Inventor 邓家刚黄慧学杨柯梁秋云
Owner 邓家刚